Zajdela F, Latarjet R
Natl Cancer Inst Monogr. 1978 Dec(50):133-40.
The induction of skin cancer in mice of the Swiss (Carshalton) strain, by repeated irradiation with UV-light, was strikingly reduced by the local application of caffeine prior to each exposure. Theophylline displayed the same activity. These two substances have been selected as probable inhibitors of error-prone, postreplicative DNA repair. Conversely, reductone and chloroquine, which are considered as inhibitors of the error-free, prereplicative excision repair, did not modify the incidence of the tumors. Special emphasis has been given to the histologic behavior of radiolabeled caffeine in the normal and UV-irradiated epidermis of the mouse in vivo and to the ability of mouse epidermal cells in vitro to repair DNA after UV irradiation.
通过紫外线反复照射，可诱导瑞士（卡沙尔顿）品系小鼠患皮肤癌，而在每次照射前局部应用咖啡因，可显著降低皮肤癌的诱导率。茶碱也表现出同样的活性。这两种物质被选定为可能的易出错的复制后DNA修复抑制剂。相反，被认为是无差错的复制前切除修复抑制剂的还原酮和氯喹，并未改变肿瘤的发生率。特别强调了放射性标记咖啡因在正常和紫外线照射的小鼠体内表皮中的组织学行为，以及体外培养的小鼠表皮细胞在紫外线照射后修复DNA的能力。
