Gao Zhong-Bao, Wang Wei, Zhao Xing-Li, Shang Yan-Chang, Bai Xiu-Juan, Wu Wei-Ping
Department of Neurology of Nanlou Division, Chinese PLA General Hospital, Beijing 100853, China.
Zhonghua Yi Xue Za Zhi. 2011 Jan 4;91(1):37-9.
To observe and assess the cognitive changes of mild cognitive impairment (MCI) in the elderly.
A cohort study design was conducted among 47 patients with MCI and 21 control selected from the same convalescent camp, Montreal cognitive assessment (MoCA), mini mental state examination (MMSE) and clock drawing test (CDT) were performed to all subjects at the onset of study and 12 months later.
The score of MMSE, CDT, MoCA and its subitems including visuospatial skill and delayed recall of MCI group were lower than the baseline after 12 months, with significantly decline in the score of MoCA (P = 0.041) and delay recall (P = 0.003). There was no obvious difference in the score of control between the baseline and that after 12 months.
The decline of delayed recall occurred early and significantly, which may be a predictor in the conversion of mild cognitive impairment to dementia.
观察和评估老年人轻度认知障碍（MCI）的认知变化。
采用队列研究设计，选取来自同一疗养院的47例MCI患者和21例对照者，在研究开始时及12个月后对所有受试者进行蒙特利尔认知评估（MoCA）、简易精神状态检查表（MMSE）和画钟试验（CDT）。
12个月后，MCI组的MMSE、CDT、MoCA及其包括视觉空间技能和延迟回忆在内的子项目得分均低于基线，MoCA得分（P = 0.041）和延迟回忆得分（P = 0.003）显著下降。对照组基线与12个月后的得分无明显差异。
延迟回忆的下降出现早且显著，可能是轻度认知障碍向痴呆转化的一个预测指标。
