[卡巴前列素对具有遗传性中风易感性的正常血压和自发性高血压大鼠心脏中ATP酶活性的影响]

[The effect of carbacyclin on the ATPase activity in the heart of normotensive and spontaneously hypertensive rats with a hereditary susceptibility to stroke].

出版信息

Biull Eksp Biol Med. 1990 Mar;109(3):229-31.

Abstract

Effects of carbacyclin, a synthetic analogue of prostacyclin on Na, K-ATPase, Ca, Mg- and Ca-ATPase activity of plasmatic membrane (PM) and sarcoplasmic reticulum (SR) of the heart normotensive (WKY) and stroke-prone spontaneously hypertensive (SHR-SP) rats were examined. In SR carbacyclin was found to increase Ca, Mg- and Ca-ATPase activity in SHR-SP and decrease the activity of this enzymes in WKY. Carbacyclin caused identical effect on ATPase activity in PM in WKY and SHR-SP, but the greatest effects were in WKY.

摘要

研究了前列环素的合成类似物卡巴前列素对正常血压（WKY）大鼠和易中风自发性高血压（SHR-SP）大鼠心脏质膜（PM）和肌浆网（SR）的钠钾ATP酶、钙镁ATP酶和钙ATP酶活性的影响。在SR中，发现卡巴前列素可增加SHR-SP中的钙镁ATP酶和钙ATP酶活性，并降低WKY中这些酶的活性。卡巴前列素对WKY和SHR-SP的PM中的ATP酶活性产生相同的影响，但对WKY的影响最大。

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