Zoloev G K
Biull Eksp Biol Med. 1990 Mar;109(3):231-4.
The experiments have been performed on 164 rats and 110 mice. Met-enkephalin and beta-endorphin concentration was established to increase in the blood in the early period after acute blood loss in rats who survived after 24 hours of a follow up in the group of animals, who died during 24 hours follow up, the momentary beta-endorphin increase was noted at the 1st minute of the experiment; met-enkephalin contents in blood wasn't essentially changed. mu-Receptors' agonist DAGO injection significantly decreased rat mortality in a posthemorrhagic period. The correlation between arterial pressure values and beta-endorphin and met-enkephalin contents in the blood wasn't defined. The opioid peptides' ability to increase the organism stability to hypoxia was determined. Beta-endorphin and met-enkephalin significance in the pathogenesis of a posthemorrhagic period in acute blood loss is being discussed.
实验在164只大鼠和110只小鼠身上进行。在急性失血后的早期，对存活24小时的大鼠进行随访，发现其血液中蛋氨酸脑啡肽和β-内啡肽浓度升高；在24小时随访期间死亡的动物组中，在实验第1分钟时发现β-内啡肽瞬间升高；血液中蛋氨酸脑啡肽含量基本未变。μ受体激动剂DAGO注射显著降低了大鼠出血后阶段的死亡率。未确定动脉压值与血液中β-内啡肽和蛋氨酸脑啡肽含量之间的相关性。确定了阿片肽增加机体对缺氧稳定性的能力。正在讨论β-内啡肽和蛋氨酸脑啡肽在急性失血后出血期发病机制中的意义。
