Department of Pediatrics, Aarhus University Hospital, Skejby, Aarhus, Denmark.
J Urol. 2011 May;185(5):1857-61. doi: 10.1016/j.juro.2010.12.068. Epub 2011 Mar 21.
The alternative treatments for enuresis have been reported with high efficacy but in noncontrolled studies. Therefore, using a prospective, single-blind, randomized, placebo controlled design we evaluated the effect of laser acupuncture on bladder reservoir function and enuresis frequency in cases of monosymptomatic nocturnal enuresis with reduced maximal voided volume.
A total of 31 patients with monosymptomatic nocturnal enuresis, with at least 3 enuretic nights per week and less than 70% of normal age related maximal voided volume without first morning void (Koff's formula), no constipation, urinary tract abnormalities, or daytime incontinence were randomized into group 1--active laser acupuncture, group 2--placebo treatment with red light and skin contact and group 3--placebo treatment with red light without skin contact. After a 2-week run-in period (when patients made home recordings of nocturnal urinary production and during 2 weekends frequency-volume charts), the patients started a 5-week treatment. During the last 2 weeks of treatment patients performed the same recordings as during the run-in period.
We found no significant effect of active laser acupuncture on maximal voided volume (first morning void excluded), maximal morning voided volume, voiding frequency, enuresis frequency before and after treatment or nocturnal urine production among the patient groups. However, we found that laser acupuncture resulted in a significant increase in average daytime voided volume. We found no effect of skin contact during placebo laser acupuncture.
Laser acupuncture is a safe but inefficient treatment for monosymptomatic nocturnal enuresis with reduced maximal voided volume. However, we found subtle effects on bladder reservoir function.
替代治疗遗尿症已被报道具有较高的疗效,但在非对照研究中。因此,我们采用前瞻性、单盲、随机、安慰剂对照设计,评估了激光针灸对膀胱储尿功能和遗尿频率的影响,用于治疗单纯性夜间遗尿症且最大排尿量减少的患者。
共有 31 例单纯性夜间遗尿症患者,每周至少有 3 次遗尿,且最大排尿量少于正常年龄相关最大排尿量的 70%,没有清晨首次排尿(Koff 公式)、无便秘、无尿路异常或日间遗尿。这些患者被随机分为三组:1 组为主动激光针灸组,2 组为红光和皮肤接触的安慰剂治疗组,3 组为无皮肤接触的红光安慰剂治疗组。在为期 2 周的导入期(患者记录夜间尿液产生情况,并在 2 个周末进行频率-容量图表记录)后,患者开始进行为期 5 周的治疗。在治疗的最后 2 周,患者进行与导入期相同的记录。
我们发现主动激光针灸对最大排尿量(不包括清晨首次排尿)、最大清晨排尿量、排尿频率、治疗前后遗尿频率或夜间尿液产生均无显著影响。然而,我们发现激光针灸可显著增加平均日间排尿量。我们发现皮肤接触在安慰剂激光针灸中没有效果。
激光针灸是一种安全但无效的治疗方法,用于治疗最大排尿量减少的单纯性夜间遗尿症。然而,我们发现其对膀胱储尿功能有微妙的影响。