Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
Chem Commun (Camb). 2011 Apr 28;47(16):4676-8. doi: 10.1039/c0cc05518b. Epub 2011 Mar 21.
G-quadruplex structure aptamer (PS2.M) can capture acridine orange (AO) from reduced graphene oxide (rGO). When the AO-PS2.M/rGO mixture is incubated with hemin, the specific binding of hemin with PS2.M results in a release of AO from PS2.M and return of AO back to rGO. Based on the quenching of fluorescence, the target hemin was detected sensitively and selectively, giving a detection limit of 50 nM.
G-四链体结构适体 (PS2.M) 可以从还原氧化石墨烯 (rGO) 中捕获吖啶橙 (AO)。当 AO-PS2.M/rGO 混合物与血红素孵育时，血红素与 PS2.M 的特异性结合导致 AO 从 PS2.M 中释放，并返回 rGO。基于荧光猝灭，目标血红素被灵敏和选择性地检测到，检测限为 50 nM。
