胞苷稳定的铜纳米簇作为一种用于检测铜离子和血红素的荧光探针。
Cytidine-stabilized copper nanoclusters as a fluorescent probe for sensing of copper ions and hemin.
作者信息
Wang Yong, Chen Tianxia, Zhang Zhengtao, Ni Yongnian
机构信息
College of Chemistry, Nanchang University Nanchang Jiangxi 330031 China
State Key Laboratory of Food Science and Technology, Nanchang University Nanchang Jiangxi 330047 China.
出版信息
RSC Adv. 2018 Feb 28;8(17):9057-9062. doi: 10.1039/c7ra11383h.
We reported a sensitive and selective fluorescence "turn on-off" strategy for detection of Cu and hemin, respectively. The fluorescence "turn on" sensor for Cu detection had a wide linear range of 0.05-2.0 μM with a limit of detection (LOD) of 0.032 μM, and the fluorescence "turn off" sensor for hemin detection possessed a wide linear range of 0.05-4.0 μM with an LOD of 0.045 μM. The sensor for Cu or hemin exhibited high selectivity over other possible substances. In addition, it was demonstrated by using various analytical characterization techniques that the fluorescence "turn on" sensor for Cu was constructed on the basis of the formation of water-soluble fluorescent copper nanoclusters (CuNCs), and the fabrication of the fluorescence "turn off" sensor for hemin was predominately based on the inner filter effect of hemin on the fluorescence of the CuNCs. Finally, the proposed fluorescence "turn on-off" sensor system was successfully applied for detection of Cu in lake water samples and hemin in duck blood samples.
我们分别报道了一种用于检测铜离子和血红素的灵敏且选择性高的荧光“开-关”策略。用于检测铜离子的荧光“开启”传感器具有0.05 - 2.0 μM的宽线性范围，检测限（LOD）为0.032 μM，而用于检测血红素的荧光“关闭”传感器具有0.05 - 4.0 μM的宽线性范围，LOD为0.045 μM。用于检测铜离子或血红素的传感器对其他可能的物质表现出高选择性。此外，通过各种分析表征技术表明，用于检测铜离子的荧光“开启”传感器是基于水溶性荧光铜纳米簇（CuNCs）的形成构建的，而用于检测血红素的荧光“关闭”传感器的制备主要基于血红素对CuNCs荧光的内滤效应。最后，所提出的荧光“开-关”传感器系统成功应用于湖水样品中铜离子的检测以及鸭血样品中血红素的检测。
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