Aleĭnik D Ia, Pevnitskiĭ L A
Biull Eksp Biol Med. 1981 Dec;92(12):701-2.
The mice of different lines were immunized twice with low doses (10(6) of sheep red blood cells (SRBC) at a 7-day interval. The immune spleen cells (ISC) from syngeneic and allogeneic mice preliminarily (14 days before) given SRBC (5 . 10(8) were transplanted into the animals at varying times before or after primary antigen administration. It was discovered that the administration of the ISC from CBA and DBA/2 mice to syngeneic mice 1 or 2 days after the priming drastically lowers the production of antibody-forming cells in the recipients in response to the repeated antigen injection. The ISC from C57BL/6 mice provided low suppressor effect. ISC transplantation one, three or six days after the priming exerted no effect on the height of the secondary immune response. Suppression of antibody formation was also obtained in the allogeneic combinations CBA ISC leads to leads to C57BL/6 and DBA/2 ISC leads to CBA. It is concluded that the spleen cells from mice immunized with SRBC are capable to suppress the development of the immunological memory of SRBC.
用低剂量（10⁶个）绵羊红细胞（SRBC）对不同品系的小鼠进行两次免疫，间隔7天。将预先（提前14天）给予SRBC（5×10⁸个）的同基因和异基因小鼠的免疫脾细胞（ISC）在初次抗原给药前或后的不同时间移植到动物体内。发现用CBA和DBA/2小鼠的ISC在致敏后1或2天给同基因小鼠，会显著降低受体对重复抗原注射产生抗体形成细胞的能力。C57BL/6小鼠的ISC产生的抑制作用较弱。在致敏后1、3或6天进行ISC移植对二次免疫反应的强度没有影响。在异基因组合CBA ISC→C57BL/6和DBA/2 ISC→CBA中也获得了抗体形成的抑制。得出的结论是，用SRBC免疫的小鼠脾细胞能够抑制SRBC免疫记忆的发展。
