Hyle Emily P, Shu Bo, Lindstrom Stephen, Klimov Alexander, Hancock Kathy, Ferraro Mary J, Traum Avram Z, Michelow Ian C
Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Pediatr Transplant. 2012 Aug;16(5):E158-61. doi: 10.1111/j.1399-3046.2011.01490.x. Epub 2011 Mar 23.
2009 H1N1 pandemic influenza was associated with increased risk for severe disease in children and the immunosuppressed. We report a case of uncomplicated pneumonia because of infection with oseltamivir-resistant 2009 H1N1 virus in an immunosuppressed pediatric renal transplant patient. Innate immunity and/or altered viral fitness may be responsible for the mild clinical phenotype of the case.
2009年甲型H1N1流感大流行与儿童及免疫功能低下者患重症疾病的风险增加有关。我们报告了一例免疫功能低下的小儿肾移植患者因感染对奥司他韦耐药的2009年甲型H1N1病毒而患单纯性肺炎的病例。先天性免疫和/或病毒适应性改变可能是该病例临床表型较轻的原因。