免疫功能低下患者的奥司他韦耐药 2009-2010 年大流行流感 A（H1N1）。
Oseltamivir-resistant 2009-2010 pandemic influenza A (H1N1) in an immunocompromised patient.
机构信息
Division of Infection Disease, Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA.
出版信息
Clin Microbiol Infect. 2010 Oct;16(10):1576-8. doi: 10.1111/j.1469-0691.2010.03212.x.
Although neuraminidase inhibitors are active against most 2009-2010 pandemic influenza A (H1N1) swine-origin strains, sporadic cases of oseltamivir resistance have been described. Since April 2009, 54 cases of oseltamivir-resistant H1N1 swine-origin have been reported in the USA (http://www.cdc.gov/flu/weekly/; accessed 1 February 2010). Approximately 1.4% of tested isolates are oseltamivir resistant. We report a patient with an underlying hematological malignancy who was hospitalized with influenza A (H1N1) swine-origin and whose strain developed oseltamivir resistance during therapy.
虽然神经氨酸酶抑制剂对大多数 2009-2010 年大流行性流感 A（H1N1）猪源株具有活性，但已描述了散发性奥司他韦耐药病例。自 2009 年 4 月以来，美国已报告了 54 例奥司他韦耐药的 H1N1 猪源病例（http://www.cdc.gov/flu/weekly/；访问日期 2010 年 2 月 1 日）。大约 1.4%的检测分离株对奥司他韦耐药。我们报告了一例患有血液系统恶性肿瘤的患者，该患者因感染 A（H1N1）猪源而住院，其流感病毒株在治疗过程中发生了奥司他韦耐药。
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