Mehri Najafi, Kambiz Eftekhari, Ahmad Khodadad, Fatemeh Farahmand, Farzaneh Motamed, Hossein Fallahi Gholam, Fatemeh Mahjoub
Gastroenterology, Children Medical Center Hospital, Tehran, Iran.
Arab J Gastroenterol. 2011 Mar;12(1):37-9. doi: 10.1016/j.ajg.2011.01.011. Epub 2011 Feb 5.
Poor compliance to therapy and antibiotic resistance are the main causes for failure of anti-Helicobacter pylori (H. pylori) therapy. The purpose of this study was to assess the effectiveness of omeprazole-based triple therapy in Iranian children.
Fifty-seven children with H. pylori-related gastroduodenal disease received 1-week triple therapy with a combination of omeprazole, amoxicillin and clarithromycin (according to the susceptibility test). Success of eradication was assessed by (13)C-urea breath test and endoscopy.
Sixty-four patients (mean age 11.3years; range 2.7-16years) were included. Eradication was successful in 84.2% (95% confidence interval, 72.8% intention to treat).
One-week triple therapy was effective for the eradication of H. pylori infection in children.
治疗依从性差和抗生素耐药性是抗幽门螺杆菌（H. pylori）治疗失败的主要原因。本研究的目的是评估基于奥美拉唑的三联疗法对伊朗儿童的有效性。
57例患有幽门螺杆菌相关胃十二指肠疾病的儿童接受了为期1周的奥美拉唑、阿莫西林和克拉霉素联合三联疗法（根据药敏试验）。通过（13）C - 尿素呼气试验和内镜检查评估根除是否成功。
纳入64例患者（平均年龄11.3岁；范围2.7 - 16岁）。根除成功率为84.2%（95%置信区间，意向性治疗为72.8%）。
为期1周的三联疗法对根除儿童幽门螺杆菌感染有效。
