Suppr超能文献

诱导多能干细胞在药物开发中的应用。

The use of induced pluripotent stem cells in drug development.

机构信息

Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.

出版信息

Clin Pharmacol Ther. 2011 May;89(5):655-61. doi: 10.1038/clpt.2011.38. Epub 2011 Mar 23.

Abstract

Induced pluripotent stem cell (iPSC) technology is revolutionizing medical science, allowing the exploration of disease mechanisms and novel therapeutic molecular targets, and offering opportunities for drug discovery and proof-of-concept studies in drug development. This review focuses on the recent advancements in iPSC technology including disease modeling and control setting in its analytical paradigm. We describe how iPSC technology is integrated into existing paradigms of drug development and discuss the potential of iPSC technology in personalized medicine.

摘要

诱导多能干细胞(iPSC)技术正在彻底改变医学科学,使人们能够探索疾病机制和新的治疗性分子靶标,并为药物发现和药物开发中的概念验证研究提供机会。本文重点介绍了 iPSC 技术的最新进展,包括其分析范式中的疾病建模和控制设置。我们描述了 iPSC 技术如何融入现有的药物开发范式,并讨论了 iPSC 技术在个性化医学中的潜力。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验