Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Clin Pharmacol Ther. 2011 May;89(5):655-61. doi: 10.1038/clpt.2011.38. Epub 2011 Mar 23.
Induced pluripotent stem cell (iPSC) technology is revolutionizing medical science, allowing the exploration of disease mechanisms and novel therapeutic molecular targets, and offering opportunities for drug discovery and proof-of-concept studies in drug development. This review focuses on the recent advancements in iPSC technology including disease modeling and control setting in its analytical paradigm. We describe how iPSC technology is integrated into existing paradigms of drug development and discuss the potential of iPSC technology in personalized medicine.
诱导多能干细胞(iPSC)技术正在彻底改变医学科学,使人们能够探索疾病机制和新的治疗性分子靶标,并为药物发现和药物开发中的概念验证研究提供机会。本文重点介绍了 iPSC 技术的最新进展,包括其分析范式中的疾病建模和控制设置。我们描述了 iPSC 技术如何融入现有的药物开发范式,并讨论了 iPSC 技术在个性化医学中的潜力。