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差示扫描量热法:用于详细表征大分子及其相互作用的热力学特性的宝贵工具。

Differential scanning calorimetry: An invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions.

作者信息

Chiu Michael H, Prenner Elmar J

机构信息

Department of Biological Sciences, University of Calgary, T2N 1N4 Calgary, AB, Canada.

出版信息

J Pharm Bioallied Sci. 2011 Jan;3(1):39-59. doi: 10.4103/0975-7406.76463.

Abstract

Differential Scanning Calorimetry (DSC) is a highly sensitive technique to study the thermotropic properties of many different biological macromolecules and extracts. Since its early development, DSC has been applied to the pharmaceutical field with excipient studies and DNA drugs. In recent times, more attention has been applied to lipid-based drug delivery systems and drug interactions with biomimetic membranes. Highly reproducible phase transitions have been used to determine values, such as, the type of binding interaction, purity, stability, and release from a drug delivery mechanism. This review focuses on the use of DSC for biochemical and pharmaceutical applications.

摘要

差示扫描量热法(DSC)是一种用于研究多种不同生物大分子和提取物热致性质的高灵敏度技术。自其早期发展以来,DSC已应用于辅料研究和DNA药物等制药领域。近年来,更多的关注集中在基于脂质的药物递送系统以及药物与仿生膜的相互作用上。高度可重复的相变已被用于确定诸如结合相互作用类型、纯度、稳定性以及药物递送机制中的释放等数值。本综述聚焦于DSC在生化和制药应用中的使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4198/3053520/3a1f816c6e09/JPBS-3-39-g001.jpg

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