日本冈山县估算肾小球滤过率与蛋白尿的关系。
The relation between estimated glomerular filtration rate and proteinuria in Okayama Prefecture, Japan.
机构信息
Department of Hygiene, Faculty of Medicine, Kagawa University, Miki, Kagawa, 761-0793, Japan.
出版信息
Environ Health Prev Med. 2011 May;16(3):191-5. doi: 10.1007/s12199-010-0183-9. Epub 2010 Oct 15.
Abstract
OBJECTIVE
We investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and proteinuria in Okayama Prefecture, Japan.
SUBJECTS AND METHODS
A total of 11030 Japanese subjects, aged between 20 and 79 years, were recruited in a cross-sectional clinical investigation study. eGFR was calculated using serum creatinine, age, and sex. Proteinuria was measured by using urine strip devices.
RESULTS
Age-related variations in eGFR were noted. Two hundred sixteen men (6.2%) and 316 women (4.2%) were diagnosed with trace positive (±) and 140 men (4.0%) and 130 women (1.7%) were diagnosed with positive (+≤) proteinuria. eGFR in subjects with +≤ proteinuria was significantly lower than that in subjects without proteinuria, in both sexes.
CONCLUSION
The present study indicates that proteinuria might be an important marker in the etiology of lower eGFR in Okayama Prefecture, Japan.
摘要
目的
我们研究了日本冈山县肾小球滤过率（eGFR）评估的肾功能与蛋白尿之间的关系。
对象与方法
本横断面临床研究共纳入 11030 名 20 至 79 岁的日本受试者。使用血清肌酐、年龄和性别计算 eGFR。使用尿条设备测量蛋白尿。
结果
观察到 eGFR 随年龄的变化。216 名男性（6.2%）和 316 名女性（4.2%）被诊断为微量阳性（±），140 名男性（4.0%）和 130 名女性（1.7%）被诊断为阳性（+≤）蛋白尿。无论男女，蛋白尿+≤的受试者的 eGFR 明显低于无蛋白尿的受试者。
结论
本研究表明，蛋白尿可能是日本冈山县 eGFR 降低的病因学中的一个重要标志物。
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