在日本健康女性中，通过生活方式改变降低收缩压与改善估算肾小球滤过率（eGFR）相关。

Decreasing systolic blood pressure is associated with improving estimated glomerular filtration rate (eGFR) with lifestyle modification in Japanese healthy women.

作者信息

Miyatake Nobuyuki, Shikata Kenichi, Makino Hirofumi, Numata Takeyuki

机构信息

Department of Hygiene, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.

出版信息

Acta Med Okayama. 2010 Oct;64(5):339-43. doi: 10.18926/AMO/40510.

DOI:10.18926/AMO/40510

PMID:20975768

Abstract

The link between changes in a subject's metabolic syndrome components and her estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese women. We used data for 53 Japanese women (46.0±10.9 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant relationships between eGFR and clinical parameters at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, eGFR was significantly increased. In addition, changes in eGFR were weakly correlated with systolic blood pressure(r=-0.306, p=0.0260). A decrease in systolic blood pressure may be associated with improving eGFR in Japanese women.

摘要

在健康的日本女性中评估了受试者代谢综合征成分变化与其估计肾小球滤过率（eGFR）之间的联系。我们使用了53名日本女性（46.0±10.9岁）的数据，并进行了为期1年的随访。eGFR由一个为日本开发的新方程定义。基线时eGFR与临床参数之间无显著关系。受试者接受了饮食和生活方式改善方面的建议。在1年随访时，eGFR显著升高。此外，eGFR的变化与收缩压呈弱相关（r=-0.306，p=0.0260）。收缩压降低可能与日本女性eGFR的改善有关。