大鼠上丘脑与胃之间功能连接的研究。
Studies on functional connections between the supraoptic nucleus and the stomach in rats.
机构信息
Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan, 250014, Shandong, People's Republic of China.
出版信息
J Physiol Sci. 2011 May;61(3):191-9. doi: 10.1007/s12576-011-0137-z. Epub 2011 Mar 24.
The present study was to investigate whether there are functional connections between the hypothalamic supraoptic nucleus (SON) and the stomach, which is the case with the paraventricular nucleus. The rats were divided into four groups. Group I: the neuronal discharge was recorded extracellularly in the NTS, DMV or SON before and after cold physiological saline (4°C) was perfused into the stomach and effused from the duodenum. Group II: the rats were stimulated as for Group I and c-Fos expression in NTS, DMV and SON was examined. Group III: the control to Group II. Group IV: gastric motility was recorded continuously before and after microinjection of L: -Glu into the SON. In Group I, the discharge frequency increased in all the three nuclei, while in Group II, Fos expression in NTS, DMV and SON was, respectively, greater than that of Group III. In Group IV, microinjection of L: -Glu (5 nmol) into SON significantly inhibited gastric motility. These data suggest there are functional connections between SON and stomach.
本研究旨在探讨下丘脑视上核（SON）与胃之间是否存在功能联系，就像室旁核那样。将大鼠分为四组。组 I：在向胃内灌注冷生理盐水（4°C）和十二指肠流出后，分别在 NTS、DMV 或 SON 中记录神经元的细胞外放电。组 II：对大鼠进行与组 I 相同的刺激，并检查 NTS、DMV 和 SON 中的 c-Fos 表达。组 III：组 II 的对照。组 IV：在 SON 内微量注射 L: -Glu 前后连续记录胃动力。在组 I 中，三个核中的放电频率均增加，而在组 II 中，NTS、DMV 和 SON 中的 Fos 表达分别大于组 III。在组 IV 中，SON 内微量注射 L: -Glu（5 nmol）显著抑制胃动力。这些数据表明 SON 和胃之间存在功能联系。
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