Pueschel S M, Hillemeier C, Caldwell M, Senft K, Mevs C, Pezzullo J C
Child Development Center, Rhode Island Hospital, Brown University Program in Medicine, Providence 02903.
J Ment Defic Res. 1990 Jun;34 ( Pt 3):269-75. doi: 10.1111/j.1365-2788.1990.tb01538.x.
The total daily vitamin A intake, physical signs associated with vitamin A deficiency, and the response to a vitamin A challenge were studied in 33 patients with Down's syndrome and in 14 intellectually normal persons (comparison group). The evaluation of detailed dietary histories revealed that the study subjects' mean daily vitamin A intake was similar to the recommended daily allowance for adults and that there was no significant difference of the mean daily vitamin A intake between study and comparison groups (5029 IU and 5706 IU, respectively). Subjects with Down's syndrome had more symptoms usually seen in patients with hypovitaminosis A than the persons in the comparison group. The baseline serum vitamin A levels in the Down's syndrome and comparison groups were within the normal range (106.0 micrograms/dl and 136.5 micrograms/dl, respectively). The vitamin A absorption curve of persons with Down's syndrome paralleled that of normal individuals and no significant difference of vitamin A levels between study and comparison groups was observed except for the 6-h values. Also, the absorption differential (delta = 3-h value + 6-h value/2-O-h value) did not show a significant difference between the two groups. Thus, these investigations do not support previous reports of significantly decreased vitamin A absorption in individuals with Down's syndrome.
对33名唐氏综合征患者和14名智力正常者（对照组）的每日维生素A总摄入量、与维生素A缺乏相关的体征以及维生素A激发试验的反应进行了研究。详细饮食史评估显示，研究对象的每日维生素A平均摄入量与成人推荐的每日摄入量相似，且研究组与对照组之间的每日维生素A平均摄入量无显著差异（分别为5029国际单位和5706国际单位）。唐氏综合征患者比对照组出现更多通常在维生素A缺乏症患者中见到的症状。唐氏综合征组和对照组的基线血清维生素A水平均在正常范围内（分别为106.0微克/分升和136.5微克/分升）。唐氏综合征患者的维生素A吸收曲线与正常个体的相似，除6小时值外，研究组与对照组之间的维生素A水平无显著差异。此外，两组之间的吸收差异（δ=3小时值+6小时值/2-0小时值）也无显著差异。因此，这些研究不支持先前关于唐氏综合征患者维生素A吸收显著降低的报道。
