矽肺患者血小板激活因子的测定及其对成纤维细胞的影响。
Determination of the platelet activating factor in silicotic patients and its effect on fibroblasts.
机构信息
Institute of Hygiene, Zhejiang Academy of Medical Sciences, China,
出版信息
Environ Health Prev Med. 2001 Jan;5(4):134-7. doi: 10.1007/BF02918288.
Platelet-activation factor (PAF), one of the potent proinflammatory mediators, is produced from a large range of cells, including polymorphonuclear neutrophils, monocytes, and natural killer cells. To study the role of PAF in the pathogenesis of silicosis, we determined the PAF in silicotic patients and in healthy persons. The results showed that the concentration of PAF in the plasma of silicotic patients was significantly higher than that of healthy persons. Ourin vitro experimental results showed that the total numbers of fibroblasts were markedly raised with added PAF from 0 to 1 μ g/ml. Adding 1 μ g/ml PAF significantly increased the total numbers of fibroblasts after culture for 48, 72, 96 hrs. Therefore, we suggest that PAF be possibly involved in the pathogenesis of silicosis. However, the mechanism remains to be further elucidated.
血小板激活因子（PAF）是一种强有力的促炎介质，可由多种细胞产生，包括多形核粒细胞、单核细胞和自然杀伤细胞。为了研究 PAF 在矽肺发病机制中的作用，我们测定了矽肺患者和健康人血浆中的 PAF。结果表明，矽肺患者血浆中 PAF 的浓度明显高于健康人。我们的体外实验结果表明，加入 PAF 后，从 0 至 1μg/ml，成纤维细胞的总数明显增加。加入 1μg/ml PAF 后，培养 48、72、96 小时后，成纤维细胞的总数明显增加。因此，我们认为 PAF 可能参与了矽肺的发病机制。然而，其机制仍有待进一步阐明。
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