Department of Molecular Biology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.
Mol Carcinog. 2011 Nov;50(11):857-62. doi: 10.1002/mc.20765. Epub 2011 Mar 22.
The genetic polymorphisms in E-cadherin gene (CDH1) may affect invasive/metastatic disease development by altering gene transcriptional activity. In this paper, we investigated the effect of 3'-UTR +54C/T polymorphism (rs1801026) in CDH1 gene on the risk and progression of several common cancers. Multiple completely independent case-control analyses of 1081 cancer patients with esophageal squamous cell carcinoma (ESCC), gastric cardiac adenocarcinoma (GCA), non-small-cell lung cancer (NSCLC), and cervical cancer and 1131 control subjects in northern Chinese populations. The results showed that the carriers with T allele were significantly decreased the risk of developing GCA, NSCLC, and cervical cancer, with an adjusted odds ratio of 0.67 (95% CI = 0.48-0.91), 0.68 (95% CI = 0.49-0.92), and 0.66 (95% CI = 0.48-0.92), respectively. There were no association between the frequency of genotype and the clinicopathological features of ESCC, GCA, and NSCLC, but the frequency of T allele was significantly lower in patients of stage III cervical cancer (P = 0.026). These results suggested that the 3'-UTR +54C/T polymorphism in CDH1 may be a marker for genetic susceptibility of cancer.
E-钙黏蛋白基因（CDH1）的遗传多态性可能通过改变基因转录活性而影响侵袭/转移疾病的发展。本文研究了 CDH1 基因 3'-UTR+54C/T 多态性（rs1801026）对几种常见癌症的风险和进展的影响。对来自中国北方人群的 1081 例食管癌（ESCC）、胃贲门腺癌（GCA）、非小细胞肺癌（NSCLC）和宫颈癌患者和 1131 例对照者进行了 10 项完全独立的病例对照分析。结果表明，T 等位基因携带者患 GCA、NSCLC 和宫颈癌的风险显著降低，调整后的比值比分别为 0.67（95%CI=0.48-0.91）、0.68（95%CI=0.49-0.92）和 0.66（95%CI=0.48-0.92）。ESCC、GCA 和 NSCLC 患者的基因型频率与临床病理特征之间无相关性，但 III 期宫颈癌患者 T 等位基因的频率显著降低（P=0.026）。这些结果表明，CDH1 基因 3'-UTR+54C/T 多态性可能是癌症遗传易感性的标志物。
