Ma Ying-Yu, Wu Wei-Quan, Liu Zheng-Chuang, Yu Xiao-Fen, Guo Kun, He Qi-Wen, Jiang Shi-Bin, Shao Qin-Shu, Tao Hou-Quan, Huang Dong-Sheng
Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China.
Digestive System Department, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China.
World J Surg Oncol. 2016 Jun 27;14(1):169. doi: 10.1186/s12957-016-0927-0.
Numerous epidemiological studies have evaluated the association between the CDH1 -160C/A polymorphism and the risk of breast cancers. However, these studies have yielded conflicting results. To derive a more precise estimation of this association, this meta-analysis was conducted.
A comprehensive search using the keywords "CDH1," "E-Cadherin," "polymorphism," "SNP," and "variant" combined with "breast," "cancer," "tumor," or "carcinomas" was conducted. Pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were appropriately calculated using a fixed effect or random effect model. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2009 checklist was used for this meta-analysis.
Four publications including five studies were identified. It was found that the CDH1 -160C/A polymorphism was significantly associated with breast cancer risk in the dominant model (CA + AA vs. CC: OR = 1.207, 95 % CI = 1.031-1.412, P = 0.019).
Our meta-analysis demonstrated that the -160C/A polymorphism in the CDH1 gene might contribute to breast cancer susceptibility. Further investigations using a much larger sample including different ethnicities are still needed to verify this association.
众多流行病学研究评估了CDH1基因-160C/A多态性与乳腺癌风险之间的关联。然而，这些研究结果相互矛盾。为了更精确地估计这种关联，进行了此项荟萃分析。
使用关键词“CDH1”“E-钙黏蛋白”“多态性”“单核苷酸多态性”“变异体”与“乳腺”“癌”“肿瘤”或“癌瘤”进行全面检索。采用固定效应或随机效应模型适当计算合并比值比（OR）及95%置信区间（CI）。本荟萃分析使用系统评价和荟萃分析的首选报告项目（PRISMA）2009清单。
共纳入4篇文献中的5项研究。结果发现，在显性模型中，CDH1基因-160C/A多态性与乳腺癌风险显著相关（CA + AA vs. CC：OR = 1.207，95% CI = 1.031 - 1.412，P = 0.019）。
我们的荟萃分析表明，CDH1基因-160C/A多态性可能与乳腺癌易感性有关。仍需使用包括不同种族的更大样本进行进一步研究以验证这种关联。
