正常人体内多巴胺能阻滞期间的钠稳态和激素反应。

Sodium homeostasis and hormonal responses during dopaminergic blockade in normal humans.

作者信息

Coruzzi P, Musiari L, Biggi A, Carra N, Ravanetti C, Minuz P, Montanari A, Novarini A

机构信息

Institute of Semeiotica Medica, University of Parma, Italy.

出版信息

Am J Hypertens. 1990 Jun;3(6 Pt 2):87S-89S. doi: 10.1093/ajh/3.6.87s.

DOI:10.1093/ajh/3.6.87s

PMID:2143391

Abstract

Six normal subjects were submitted to 2 h water immersion (WI) with and without pharmacological dopaminergic (DA) blockade with metoclopramide (MCP). Urinary sodium excretion showed a marked increase during WI alone while it was blunted during WI plus DA blockade. Plasma aldosterone was significantly suppressed by WI alone but remained unchanged during WI plus MCP. Plasma atrial natriuretic factor showed similar augmentation during WI alone and during WI plus MCP. The reduced sodium and 6-keto-PGF1 alpha excretion, observed during WI plus MCP administration, suggests that dopamine might induce prostacyclin synthesis in the kidney during WI.

摘要

六名正常受试者接受了两种情况的两小时水浸（WI）：一种是未使用药物多巴胺能（DA）阻断剂甲氧氯普胺（MCP），另一种是使用了该阻断剂。单独水浸期间尿钠排泄显著增加，而在水浸加多巴胺能阻断期间则受到抑制。单独水浸可显著抑制血浆醛固酮，但在水浸加甲氧氯普胺期间保持不变。单独水浸期间和水浸加甲氧氯普胺期间血浆心钠素均有类似增加。在水浸加甲氧氯普胺给药期间观察到的钠和6-酮-前列腺素F1α排泄减少，提示多巴胺可能在水浸期间诱导肾脏中前列环素的合成。