Ogihara T, Shima J, Hara H, Tabuchi Y, Hashizume K, Nagano M, Katahira K, Kangawa K, Matsuo H, Kumahara Y
Life Sci. 1986 Jun 30;38(26):2413-8. doi: 10.1016/0024-3205(86)90610-7.
To investigate the physiological regulatory mechanism of human atrial natriuretic polypeptide (hANP) secretion, plasma hANP was measured by a direct radioimmunoassay during head-out total body water immersion (WI) in normal men. Five healthy men were immersed in water for 1 hr. Urine volume and Na excretion were significantly increased during WI. Plasma hANP increased significantly during WI peaking at 30 min. and returned toward the baseline after WI. Plasma renin activity and norepinephrine were suppressed occasionally during WI. Plasma ADH did not change throughout the study period. Maximal increments in plasma hANP correllated with that in urine output or urinary Na excretion during WI. These data suggest that acute central hypervolemia caused by WI increases hANP secretion and that this increase may participate in the diuretic response to WI.
为研究人心房利钠多肽（hANP）分泌的生理调节机制，采用直接放射免疫分析法对正常男性进行头低位全身水浸（WI）时的血浆hANP进行了测定。5名健康男性被浸于水中1小时。水浸期间尿量和钠排泄量显著增加。水浸期间血浆hANP显著升高，在30分钟时达到峰值，水浸后恢复至基线水平。水浸期间血浆肾素活性和去甲肾上腺素偶尔受到抑制。整个研究期间血浆抗利尿激素（ADH）未发生变化。水浸期间血浆hANP的最大增幅与尿量或尿钠排泄量的最大增幅相关。这些数据表明，水浸引起的急性中枢性血容量过多会增加hANP分泌，且这种增加可能参与了对水浸的利尿反应。
