Baryshnikov E N, Drozdov V N, Shuliat'ev I S, Parfenov A I, Lazebnik L B
Eksp Klin Gastroenterol. 2010(10):25-8.
Adjusting therapy of patients with ulcerative colitis (UC) regarding their cytomegalovirus (CMV)--status.
40 patients were included, mean age--44.3 +/- 3.2 yo. DNA CMV was detected in mucosal tissue samples from rectum using real-time PCR.
4 (10%) were CMV-positive. CMV-positive status rate was higher among patients on therapy with immunomodulators 3 (23.1%) vs 1 in patients on steroids and/or salicylates. There was significantly higher rate of severe disease and steroid dependence among CMV-positive patients than among CMV-negative: 75% vs 13.9%, 75% vs 8.3% correspondently.
CMV-infection is associated with severe and steroid-dependent UC.
根据巨细胞病毒（CMV）状态调整溃疡性结肠炎（UC）患者的治疗方案。
纳入40例患者，平均年龄为44.3±3.2岁。使用实时聚合酶链反应（PCR）在直肠黏膜组织样本中检测CMV DNA。
4例（10%）为CMV阳性。接受免疫调节剂治疗的患者中CMV阳性率更高，为3例（23.1%），而接受类固醇和/或水杨酸盐治疗的患者中为1例。CMV阳性患者中重症疾病和类固醇依赖的发生率显著高于CMV阴性患者：分别为75%对13.9%，75%对8.3%。
CMV感染与重度和类固醇依赖型UC相关。
