Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain.
J Cell Mol Med. 2011 Dec;15(12):2594-600. doi: 10.1111/j.1582-4934.2011.01312.x.
Blood vessels are highly organized and complex structure, which are far more than simple tubes conducting the blood to almost any tissue of the body. The fine structure of the wall of blood vessels has been studied previously using the electron microscope, but the presence the telocytes associated with vasculature, a specific new cellular entity, has not been studied in depth. Interestingly, telocytes have been recently found in the epicardium, myocardium, endocardium, human term placenta, duodenal lamina propria and pleura. We show the presence of telocytes located on the extracellular matrix of blood vessels (arterioles, venules and capillaries) by immunohistochemistry and transmission electron microscopy. Also, we demonstrated the first evidence of a primary cilium in telocytes. Several functions have been proposed for these cells. Here, the telocyte-blood vessels cell proximity, the relationship between telocytes, exosomes and nervous trunks may have a special significance.
血管是高度组织化和复杂的结构，它们远远不止是将血液输送到身体几乎任何组织的简单管道。以前已经使用电子显微镜研究了血管壁的精细结构，但与脉管系统相关的特定新型细胞实体—— 间质细胞，尚未得到深入研究。有趣的是，间质细胞最近在心脏的心外膜、心肌、心内膜、人足月胎盘、十二指肠固有层和胸膜中被发现。我们通过免疫组织化学和透射电子显微镜显示了位于血管（小动脉、小静脉和毛细血管）细胞外基质上的间质细胞的存在。此外，我们还证明了间质细胞中初级纤毛的存在。已经提出了这些细胞的几种功能。在这里，间质细胞-血管细胞的接近度、间质细胞之间、外泌体和神经干之间的关系可能具有特殊意义。
