Department of ObGyn, The Reading Hospital and Medical Center, Reading, PA, USA.
J Low Genit Tract Dis. 2011 Jul;15(3):189-94. doi: 10.1097/LGT.0b013e318200497b.
To determine whether metastatic mammary carcinoma can be detected on cervical cytology in patients with atypical glandular cells (AGCs).
This blinded study of AGC cases with a matched control group was approved by Hartford Hospital institutional review board. Between January 2002 and November 2008, inclusive, all Pap tests in our database with AGC were identified. The AGC cases from patients with breast disease, compared with the control group of AGC patients without breast disease, were reanalyzed independently by 2 pathologists.
Among the 40 women who had an AGC Pap test with breast disease, 21 cases were available for review (16 with invasive and 5 with in situ breast lesions). Seventeen cases of AGC in patients without breast disease served as the control group. The 2 pathologists agreed with the original Pap finding (AGC) in 84.2% to 89.5% of cases. There were no cases, either among those with breast disease or those without, where cells consistent with breast disease were seen, nor were "tamoxifen cells" identified, on Pap testing.
Studies have found that an association exists between patients with AGCs on cervical cytology and extrauterine malignancies, including breast disease. The results of this analysis would suggest that, at least for breast disease, the higher association of cancer or precancerous lesions in those with AGC is not related to the direct extension of disease or metastasis. Further research will be needed to help delineate the potential etiology of this association.
确定在具有非典型腺细胞（AGC）的患者的宫颈细胞学检查中是否可以检测到转移性乳腺腺癌。
这项 AGC 病例的盲法研究包括一个匹配的对照组，得到了哈特福德医院机构审查委员会的批准。在 2002 年 1 月至 2008 年 11 月之间，我们的数据库中所有 AGC 的巴氏涂片检查均被确定。与没有乳腺疾病的 AGC 患者的对照组相比，对来自患有乳腺疾病的患者的 AGC 病例由 2 位病理学家独立重新分析。
在患有 AGC 巴氏涂片检查和乳腺疾病的 40 名女性中，有 21 例可用于复查（16 例有浸润性和 5 例原位乳腺病变）。作为对照组的 17 例无乳腺疾病的 AGC 患者。2 位病理学家对 84.2%至 89.5%的病例的原始巴氏涂片检查结果（AGC）达成一致。无论是在患有乳腺疾病的患者中还是在没有乳腺疾病的患者中，均未发现与乳腺疾病一致的细胞，也未在巴氏涂片检查中发现“他莫昔芬细胞”。
研究发现，宫颈细胞学检查中具有 AGC 的患者与子宫外恶性肿瘤之间存在关联，包括乳腺疾病。这项分析的结果表明，至少对于乳腺疾病，AGC 患者中癌症或癌前病变的更高关联与疾病的直接扩展或转移无关。需要进一步研究来帮助阐明这种关联的潜在病因。
