鼻型NK细胞淋巴瘤伴肺部广泛受累：一例报告
NK cell lymphoma, nasal type, with massive lung involvement: a case report.
作者信息
Morovic Anamarija, Aurer Igor, Dotlic Snjezana, Weisenburger Dennis D, Nola Marin
出版信息
J Hematop. 2010 Mar 24;3(1):19-22. doi: 10.1007/s12308-009-0050-z.
Abstract
Extranodal NK/T cell lymphoma, nasal type, is an Epstein-Barr virus-associated lymphoma that most commonly involves the nasal cavity and upper respiratory tract. Lung involvement by NK/T cell lymphoma is rare and seldom reported in the literature. We describe the unusual case of a 41-year-old male with NK cell lymphoma, nasal type, who presented with massive secondary lung involvement 2.5 years after the detection of a retroperitoneal mass. The diagnosis was made by open lung biopsy. Despite aggressive treatment, the patient died shortly after the initiation of therapy. Lung involvement by NK/T cell lymphoma occurs most commonly as part of widely disseminated disease and carries a poor prognosis for the patient. Novel agents and innovative therapies need to be developed for this aggressive lymphoma.
摘要
结外NK/T细胞淋巴瘤，鼻型，是一种与EB病毒相关的淋巴瘤，最常累及鼻腔和上呼吸道。NK/T细胞淋巴瘤累及肺部罕见，文献报道较少。我们描述了一例不寻常的病例，一名41岁男性患有鼻型NK细胞淋巴瘤，在发现腹膜后肿块2.5年后出现大量继发性肺部受累。通过开胸肺活检确诊。尽管进行了积极治疗，患者在治疗开始后不久死亡。NK/T细胞淋巴瘤累及肺部最常见于广泛播散性疾病，患者预后较差。需要为这种侵袭性淋巴瘤开发新的药物和创新疗法。
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