Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea.
Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2017 Oct;32(10):1727-1730. doi: 10.3346/jkms.2017.32.10.1727.
Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL) is a rare type of lymphoma that accounts for only 5%-18% of all cases of non-Hodgkin lymphoma (NHL). In published series, 60%-90% of NK/T-cell lymphomas are localized to the nasal and upper airway. We describe a 55-year man who presented with cough, sputum, dyspnea on exertion, and a chest computed tomography scan shows diffuse ground glass opacities (GGOs), suggestive of an interstitial lung disease. He was treated with a corticosteroid and his symptoms improved. However, when the corticosteroid was tapered, his symptoms recurred. The patient underwent a surgical lung biopsy and ENKTCL was diagnosed. We present this case because ENKTCL involving only the lung is very rare but very informative. To our knowledge, our patient is the first case that primary pulmonary ENKTCL is presented with GGOs.
结外 NK/T 细胞淋巴瘤，鼻型（ENKTCL）是一种罕见的淋巴瘤，仅占所有非霍奇金淋巴瘤（NHL）病例的 5%-18%。在已发表的系列研究中，60%-90%的 NK/T 细胞淋巴瘤局限于鼻腔和上呼吸道。我们描述了一位 55 岁男性，因咳嗽、咳痰、活动时呼吸困难就诊，胸部计算机断层扫描显示弥漫性磨玻璃影（GGOs），提示间质性肺病。他接受了皮质类固醇治疗，症状改善。然而，当皮质类固醇减量时，他的症状再次出现。患者接受了外科肺活检，诊断为 ENKTCL。我们提出这个病例，是因为仅累及肺部的 ENKTCL 非常罕见但非常有启发性。据我们所知，我们的患者是首例以 GGOs 为表现的原发性肺 ENKTCL。
