Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Clin Exp Nephrol. 2011 Aug;15(4):493-503. doi: 10.1007/s10157-011-0430-4. Epub 2011 Mar 25.
The Committee for the Standardization of Renal Pathological Diagnosis and the Working Group for Renal Biopsy Database of the Japanese Society of Nephrology started the first nationwide, web-based, and prospective registry system, the Japan Renal Biopsy Registry (J-RBR), to record the pathological, clinical, and laboratory data of renal biopsies in 2007.
The patient data including age, gender, laboratory data, and clinical and pathological diagnoses were recorded on the web page of the J-RBR, which utilizes the system of the Internet Data and Information Center for Medical Research in the University Hospital Medical Information Network. We analyzed the clinical and pathological diagnoses registered on the J-RBR in 2007 and 2008.
Data were collected from 818 patients from 18 centers in 2007 and 1582 patients from 23 centers in 2008, including the affiliated hospitals. Renal biopsies were obtained from 726 native kidneys (88.8%) and 92 renal grafts (11.2%) in 2007, and 1400 native kidneys (88.5%) and 182 renal grafts (11.5%) in 2008. The most common clinical diagnosis was chronic nephritic syndrome (47.4%), followed by nephrotic syndrome (16.8%) and renal transplantation (11.2%) in 2007. A similar frequency of the clinical diagnoses was recognized in 2008. Of the native kidneys, the most frequent pathological diagnosis as classified by pathogenesis was immunoglobulin (Ig) A nephropathy (IgAN) both in 2007 (32.9%) and 2008 (30.2%). Among the primary glomerular diseases (except IgAN), membranous nephropathy (MN) was the most common disease both in 2007 (31.4%) and 2008 (25.7%).
In a cross-sectional study, the J-RBR has shown IgAN to be the most common disease in renal biopsies in 2007 and 2008, consistent with previous Japanese studies. MN predominated in the primary glomerular diseases (except for IgAN). The frequency of the disease and the clinical and demographic correlations should be investigated in further analyses by the J-RBR.
日本肾脏病学会的肾脏病理诊断标准化委员会和肾脏活检数据库工作组于 2007 年启动了首个全国性、基于网络的前瞻性注册系统——日本肾脏活检注册系统（J-RBR），以记录肾脏活检的病理、临床和实验室数据。
患者数据包括年龄、性别、实验室数据以及临床和病理诊断，均记录在 J-RBR 的网页上，该网页利用大学医院医疗信息网络中的互联网数据和信息中心系统。我们分析了 2007 年和 2008 年在 J-RBR 上注册的临床和病理诊断。
2007 年从 18 个中心收集了 818 例患者的数据，2008 年从 23 个中心包括附属医院收集了 1582 例患者的数据。2007 年，肾脏活检取自 726 个固有肾脏（88.8%）和 92 个肾移植（11.2%），2008 年取自 1400 个固有肾脏（88.5%）和 182 个肾移植（11.5%）。最常见的临床诊断是慢性肾炎综合征（47.4%），其次是肾病综合征（16.8%）和肾移植（11.2%）。2008 年的临床诊断频率相似。在固有肾脏中，按发病机制分类的最常见病理诊断是免疫球蛋白（Ig）A 肾病（IgAN），2007 年和 2008 年均为 32.9%。在原发性肾小球疾病（除 IgAN 外）中，膜性肾病（MN）在 2007 年（31.4%）和 2008 年（25.7%）均为最常见疾病。
在一项横断面研究中，J-RBR 显示 IgAN 是 2007 年和 2008 年肾脏活检中最常见的疾病，与之前的日本研究一致。MN 在原发性肾小球疾病（除 IgAN 外）中占主导地位。J-RBR 应进一步分析疾病频率以及临床和人口统计学相关性。
