Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Sun Yat-Sen University, No. 58, Zhongshan 2nd Road, 510080, Guangzhou, China.
Rheumatol Int. 2012 Jun;32(6):1727-31. doi: 10.1007/s00296-011-1880-4. Epub 2011 Mar 25.
Pulmonary arterial hypertension (PAH) is a devastating complication of systemic lupus erythematosus (SLE). We aim to estimate the putative predictors contributing to early identification of PAH, thus improve appropriate medical intervention and a better prognosis. A retrospective case-control study was conducted. Forty-one SLE patients with PAH and 106 SLE patients without PAH were enrolled. Demographic variables, clinical features, and laboratory data were compared between the two groups. Univariate and multivariate logistic regression models were used to examine the predictors contributing to PAH in SLE. Serositis, Raynaud's phenomenon, high disease activity, anticardiolipin antibodies, and anti-U1RNP were significantly associated with SLE-PAH. Univariate and multivariate analysis showed that Raynaud's phenomenon, anticardiolipin antibodies, and anti-U1RNP were independent predictors of PAH in SLE. This study highlighted the clinical pattern of SLE-PAH patients, and underlined the leading predictors of PAH development among patients with SLE. Routine echocardiography is recommended in SLE patients with the independent predictors mentioned above.
特发性肺动脉高压（PAH）是系统性红斑狼疮（SLE）的一种严重并发症。我们旨在评估可能有助于早期识别 PAH 的预测因素，从而改善适当的医疗干预和预后。进行了一项回顾性病例对照研究。共纳入 41 例 PAH 的 SLE 患者和 106 例无 PAH 的 SLE 患者。比较两组之间的人口统计学变量、临床特征和实验室数据。使用单因素和多因素逻辑回归模型来检查 SLE 中导致 PAH 的预测因素。胸膜炎、雷诺现象、高疾病活动度、抗心磷脂抗体和抗 U1RNP 与 SLE-PAH 显著相关。单因素和多因素分析表明，雷诺现象、抗心磷脂抗体和抗 U1RNP 是 SLE 中 PAH 的独立预测因素。本研究强调了 SLE-PAH 患者的临床模式，并强调了 SLE 患者中 PAH 发展的主要预测因素。建议对具有上述独立预测因素的 SLE 患者进行常规超声心动图检查。
