Department of Pediatrics, Faculty of Medical Science, State University of Campinas, Campinas, Brazil.
Rheumatol Int. 2012 May;32(5):1403-5. doi: 10.1007/s00296-011-1864-4. Epub 2011 Mar 25.
Koebner phenomenon is defined as a nonspecific skin stimulus eliciting a disease skin reaction. The nature of the skin trauma varies greatly and includes areas of thermal injury, excoriations, surgical incisions, and scars. We report a patient with recent onset of systemic lupus erythematosus who developed Herpes zoster on immunosuppressant medication. Two weeks after resolution of the vesicles, the patient presented with new ulcerative reddish lesions over the herpes zoster scare and worsening of her malar rash without evidence of worsening of any other organ. Koebner phenomenon was suspected. We review the literature on Koebner phenomenon in SLE.
科布纳现象定义为一种非特异性皮肤刺激引起的疾病皮肤反应。皮肤创伤的性质差异很大,包括热损伤、擦伤、手术切口和疤痕。我们报告了一例系统性红斑狼疮患者在免疫抑制剂治疗期间发生带状疱疹。水疱消退后两周,患者在带状疱疹疤痕上出现新的溃疡性红色病变,并且颊部皮疹恶化,而没有任何其他器官恶化的证据。怀疑出现科布纳现象。我们回顾了 SLE 中科布纳现象的文献。