Lee Nicole Y, Daniel Alyssa S, Dasher David A, Morrell Dean S
School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Pediatr Dermatol. 2013 Nov-Dec;30(6):e110-3. doi: 10.1111/j.1525-1470.2012.01776.x. Epub 2012 May 29.
Koebner isomorphic response describes the phenomenon of histopathologically identical skin lesions of a preceding cutaneous disease appearing in sites of trauma. Wolf isotopic response describes the phenomenon of a new skin disease appearing in the site of an unrelated cutaneous disease. Neither of the phenomena has been reported in relation to systemic lupus erythematosus. This report describes a 17-year-old girl with systemic lupus erythematosus exhibiting particularly severe cutaneous involvement confined primarily to sun-exposed areas presenting with a dermatomal band of atrophic, scaling, erythematous papules, and plaques on her left shoulder extending down her left arm after herpes zoster eruption. The histopathologil result showed lupus erythematosus. This phenomenon is best considered as a Koebner isomorphic response, although Wolf isotopic response has some clinical relevance as well. Koebner isomorphic and Wolf isotopic responses are discussed as related to this case.
同形反应描述了先前皮肤病的组织病理学相同的皮肤病变出现在创伤部位的现象。沃尔夫同形反应描述了一种新的皮肤病出现在无关皮肤病部位的现象。这两种现象均未被报道与系统性红斑狼疮相关。本报告描述了一名17岁的系统性红斑狼疮女孩，其皮肤受累特别严重，主要局限于暴露于阳光的部位，在带状疱疹发作后，其左肩出现沿左臂向下延伸的带状萎缩、鳞屑性红斑丘疹和斑块。组织病理学结果显示为红斑狼疮。尽管沃尔夫同形反应也有一定临床相关性，但这种现象最好被视为同形反应。本文就该病例讨论了同形反应和沃尔夫同形反应。
