Department of Pediatric Pulmonology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania 15201, USA.
Pediatr Pulmonol. 2011 Jun;46(6):604-9. doi: 10.1002/ppul.21414. Epub 2011 Mar 24.
High-frequency chest compression (HFCC) is a therapy for cystic fibrosis (CF). We hypothesized that the resonant frequency (f(res)), as measured by impulse oscillometry, could be used to determine what HFCC vest settings produce maximal airflow or volume in pediatric CF patients. In 45 subjects, we studied: f(res), HFCC vest frequencies that subjects used (f(used)), and the HFCC vest frequencies that generated the greatest volume (f(vol)) and airflow (f(flow)) changes as measured by pneumotachometer. Median f(used) for 32 subjects was 14 Hz (range, 6-30). The rank order of the three most common f(used) was 15 Hz (28%) and 12 Hz (21%); three frequencies tied for third: 10, 11, and 14 Hz (5% each). Median f(res) for 43 subjects was 20.30 Hz (range, 7.85-33.65). Nineteen subjects underwent vest-tuning to determine f(vol) and f(flow). Median f(vol) was 8 Hz (range, 6-30). The rank order of the three most common f(vol) was: 8 Hz (42%), 6 Hz (32%), and 10 Hz (21%). Median f(flow) was 26 Hz (range, 8-30). The rank order of the three most common f(flow) was: 30 Hz (26%) and 28 Hz (21%); three frequencies tied for third: 8, 14, and 18 Hz (11% each). There was no correlation between f(used) and f(flow) (r(2) = -0.12) or f(vol) (r(2) = 0.031). There was no correlation between f(res) and f(flow) (r(2) = 0.19) or f(vol) (r(2) = 0.023). Multivariable analysis showed no independent variables were predictive of f(flow) or f(vol). Vest-tuning may be required to optimize clinical utility of HFCC. Multiple HFCC frequencies may need to be used to incorporate f(flow) and f(vol).
高频胸壁振荡（HFCC）是囊性纤维化（CF）的一种治疗方法。我们假设，通过脉冲振荡测量得到的共振频率（f(res)）可以用于确定在儿科 CF 患者中，哪种 HFCC 背心设置可以产生最大的气流或容量。在 45 名受试者中，我们研究了：f(res)、受试者使用的 HFCC 背心频率（f(used)）以及通过气流计测量产生最大体积（f(vol)）和气流（f(flow)）变化的 HFCC 背心频率。32 名受试者的中位 f(used)为 14 Hz（范围，6-30 Hz）。三种最常见的 f(used)的排序是 15 Hz（28%）和 12 Hz（21%）；三个频率并列第三：10、11 和 14 Hz（各 5%）。43 名受试者的中位 f(res)为 20.30 Hz（范围，7.85-33.65 Hz）。19 名受试者接受了背心调谐以确定 f(vol)和 f(flow)。中位 f(vol)为 8 Hz（范围，6-30 Hz）。三种最常见的 f(vol)的排序是：8 Hz（42%）、6 Hz（32%）和 10 Hz（21%）。中位 f(flow)为 26 Hz（范围，8-30 Hz）。三种最常见的 f(flow)的排序是：30 Hz（26%）和 28 Hz（21%）；三个频率并列第三：8、14 和 18 Hz（各 11%）。f(used)与 f(flow)（r(2) = -0.12）或 f(vol)（r(2) = 0.031）之间没有相关性。f(res)与 f(flow)（r(2) = 0.19）或 f(vol)（r(2) = 0.023）之间也没有相关性。多变量分析显示，没有独立变量可以预测 f(flow)或 f(vol)。可能需要背心调谐来优化 HFCC 的临床实用性。可能需要使用多种 HFCC 频率来结合 f(flow)和 f(vol)。
