Florey Neuroscience Institutes, Parkville, Victoria 3010, Australia.
Brain Res. 2011 May 19;1391:54-9. doi: 10.1016/j.brainres.2011.03.045. Epub 2011 Mar 23.
A role for orexin A in mediating the primary and conditioned reinforcing effects of alcohol has been established. It is unclear however whether the contribution of orexins to alcohol reward occurs independently of effects on appetite and feeding, and whether orexins regulate the motivation to consume alcohol compared to other rewards. To examine this further here we investigate the effect of the orexin(1) receptor antagonist, SB-334867, on self-administration of alcohol (10% v/v) under both fixed (FR) and progressive ratio (PR) schedules of reinforcement, and whether this differs from the motivation to administer a natural food reward, sucrose (0.2-0.7% w/v) in alcohol preferring (iP) rats. SB-334867 treatment significantly reduced responding for both alcohol and sucrose under a FR3 schedule; however, at the same dose, reduced responding and break point for ethanol, but not sucrose, under a PR schedule. These findings for the first time implicate a role for orexins in the motivation to self-administer alcohol and suggest that this may occur independent of any generalized effect on appetitive drive.
已确定食欲素 A 在介导酒精的主要和条件强化作用中发挥作用。然而，尚不清楚食欲素对酒精奖赏的贡献是否独立于对食欲和摄食的影响，以及食欲素是否调节与其他奖赏相比饮酒的动机。为了进一步研究这一点，我们研究了食欲素（1）受体拮抗剂 SB-334867 对酒精（10% v/v）自我给药的影响，在固定（FR）和递增比例（PR）强化方案下，以及这种影响与酒精偏好（iP）大鼠中给予天然食物奖励蔗糖（0.2-0.7% w/v）的动机是否不同。SB-334867 处理显著减少了 FR3 方案下酒精和蔗糖的反应；然而，在相同剂量下，减少了 PR 方案下乙醇而非蔗糖的反应和突破点。这些发现首次表明，食欲素在自我给药酒精的动机中发挥作用，并表明这可能独立于对食欲驱动的任何普遍影响。
