Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA.
Horm Behav. 2011 Jun;60(1):86-93. doi: 10.1016/j.yhbeh.2011.03.009. Epub 2011 Apr 1.
Estradiol (E2) exerts an inhibitory effect on food intake in a variety of species. While compelling evidence indicates that central, rather than peripheral, estrogen receptors (ERs) mediate this effect, the exact brain regions involved have yet to be conclusively identified. In order to identify brain regions that are sufficient for E2's anorectic effect, food intake was monitored for 48 h following acute, unilateral, microinfusions of vehicle and two doses (0.25 and 2.5 μg) of a water-soluble form of E2 in multiple brain regions within the hypothalamus and midbrain of ovariectomized rats. Dose-related decreases in 24-h food intake were observed following E2 administration in the medial preoptic area (MPOA), arcuate nucleus (ARC), and dorsal raphe nucleus (DRN). Within the former two brain areas, the larger dose of E2 also decreased 4-h food intake. Food intake was not influenced, however, by similar E2 administration in the paraventricular nucleus, lateral hypothalamus, or ventromedial nucleus. These data suggest that E2-responsive neurons within the MPOA, ARC, and DRN participate in the estrogenic control of food intake and provide specific brain areas for future investigations of the cellular mechanism underlying estradiol's anorexigenic effect.
雌二醇（E2）在多种物种中对摄食具有抑制作用。虽然有强有力的证据表明，中枢而非外周雌激素受体（ER）介导了这种作用，但确切的涉及脑区尚未得到明确鉴定。为了确定大脑区域是 E2 产生厌食作用所必需的，在去卵巢大鼠下丘脑和中脑的多个脑区中，急性单侧微注射载体和两种剂量（0.25 和 2.5μg）水溶性 E2 后，监测 48 小时的食物摄入量。在中脑导水管周围灰质（MPOA）、弓状核（ARC）和中缝背核（DRN）中，E2 给药后观察到 24 小时食物摄入量呈剂量相关性下降。然而，在这两个前脑区域，较大剂量的 E2 也降低了 4 小时的食物摄入量。然而，类似的 E2 给药对室旁核、下丘脑外侧区或腹内侧核的食物摄入量没有影响。这些数据表明，MPOA、ARC 和 DRN 内的 E2 反应神经元参与了雌激素对食物摄入的控制，并为进一步研究雌激素的厌食作用的细胞机制提供了特定的脑区。
