猫体内（99m）锝-二巯基丁二酸的绝对和相对肾摄取：操作方法及正常值
(99m)Tc-DMSA absolute and relative renal uptake in cats: procedure and normal values.
作者信息
Vandermeulen Eva, Ham Hamphrey R, Dobbeleir André A, De Sadeleer Carlos, Piepsz Amy, Waelbers Tim, Vermeire Simon T, Slegers Guido, Peremans Kathelijne Y
机构信息
Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium.
出版信息
J Feline Med Surg. 2011 Jun;13(6):387-92. doi: 10.1016/j.jfms.2010.12.005. Epub 2011 Mar 25.
In this study we investigated the influence of technical factors (positioning, background (BG) correction and attenuation correction) on qualitative and quantitative (absolute (AU) and relative (RU) uptake) assessment of feline kidneys with (99m)technetium labelled dimercaptosuccinic acid ((99m)Tc-DMSA). Eleven healthy adult cats were included. Influence of BG and depth correction on quantitative assessment was evaluated. Depth correction was based on the geometric mean method (using dorsal and ventral images) and the use of two standards placed over each individual kidney. Visual evaluation showed superiority of dorsal and ventral over lateral positioning due to increased separation of the kidneys permitting region of interest (ROI) placement without overlap. No apparent influence of BG correction was found for RU. However, AU was systematically overestimated without BG correction. Depth correction did not seem to affect RU in most cases, however, in some cats the differences were not negligible. The values for AU without depth correction were lower compared to depth corrected values.
在本研究中，我们使用（99m）锝标记的二巯基丁二酸（（99m）Tc-DMSA），研究了技术因素（定位、背景（BG）校正和衰减校正）对猫肾脏定性和定量（绝对摄取量（AU）和相对摄取量（RU））评估的影响。纳入了11只健康成年猫。评估了BG和深度校正对定量评估的影响。深度校正基于几何平均法（使用背侧和腹侧图像）以及在每个肾脏上方放置两个标准物。视觉评估显示，由于肾脏间距增加，背侧和腹侧定位优于侧位定位，使得感兴趣区（ROI）放置时不会重叠。未发现BG校正对RU有明显影响。然而，在没有BG校正的情况下，AU被系统性高估。在大多数情况下，深度校正似乎不影响RU，但是，在一些猫中，差异不可忽略。与深度校正后的值相比，未进行深度校正时的AU值较低。
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