ReAct, Action on Antibiotic Resistance, Uppsala University, SE-751 05 Uppsala, Sweden.
Drug Resist Updat. 2011 Apr;14(2):70-6. doi: 10.1016/j.drup.2011.01.007. Epub 2011 Mar 26.
To highlight the global need for effective antibiotics and explore possible concerted actions for change, cross-cutting plenary sessions served to frame the program of the conference. These sessions contained presentations on the present state of antibacterial resistance and the availability, the use and misuse of antibiotics. A number of possible actions were discussed, such as rational use of and access to antibiotics from various perspectives. The roles of vaccines and diagnostics were touched upon and followed by in depth discussions on supply-side bottlenecks with their scientific, regulatory and financial challenges. The value chain for research and development (R&D) of antibiotics has to be reengineered if we are to realize the development of much needed new antibiotics. This challenge will require a multitude of actions, some of which are related to changing the financial realities of antibiotics and interventions by global and regional institutions.
为了强调全球对抗生素的有效需求，并探讨可能采取的协同行动来改变现状，跨领域全体会议为会议的议程提供了框架。这些会议包含了关于当前抗菌药物耐药性的状况以及抗生素的供应、使用和滥用情况的介绍。会议还讨论了一些可能的行动，例如从不同角度合理使用和获得抗生素。会议还提到了疫苗和诊断的作用，并随后深入讨论了供应方面的瓶颈问题及其所面临的科学、监管和财政挑战。如果我们要实现急需的新型抗生素的开发，就必须对抗生素研发的价值链进行重新设计。这一挑战需要采取多种行动，其中一些与改变抗生素的财务现状以及全球和地区机构的干预措施有关。
