Brownstein Deborah, Miller Melissa A, Oates Stori C, Byrne Barbara A, Jang Spencer, Murray Michael J, Gill Verena A, Jessup David A
California Department of Fish and Game, Marine Wildlife Veterinary Care and Research Center, 1451 Shaffer Rd. Santa Cruz, California 95060, USA.
J Wildl Dis. 2011 Apr;47(2):278-92. doi: 10.7589/0090-3558-47.2.278.
Bacterial infections are an important cause of sea otter (Enhydra lutris) mortality, and some of these infections may originate from terrestrial and anthropogenic sources. Antimicrobials are an important therapeutic tool for management of bacterial infections in stranded sea otters and for prevention of infection following invasive procedures in free-ranging otters. In this study, susceptibility to commonly used antimicrobials was determined for 126 isolates of 15 bacterial species or groups from necropsied, live-stranded injured or sick, and apparently healthy wild sea otters examined between 1998 and 2005. These isolates included both gram-positive and gram-negative strains of primary pathogens, opportunistic pathogens, and environmental flora, including bacterial species with proven zoonotic potential. Minimal evidence of antimicrobial resistance and no strains with unusual or clinically significant multiple-drug resistance patterns were identified. Collectively, these findings will help optimize selection of appropriate antimicrobials for treatment of bacterial diseases in sea otters and other marine species.
细菌感染是海獭（Enhydra lutris）死亡的一个重要原因，其中一些感染可能源自陆地和人为来源。抗菌药物是治疗搁浅海獭细菌感染以及预防自由放养海獭侵入性操作后感染的重要治疗工具。在本研究中，测定了1998年至2005年间对126株分离菌的常用抗菌药物敏感性，这些分离菌来自尸检、活体搁浅受伤或患病以及看似健康的野生海獭，分属于15个细菌物种或菌群。这些分离菌包括主要病原体、机会性病原体和环境菌群的革兰氏阳性和革兰氏阴性菌株，其中包括具有已证实的人畜共患病潜力的细菌物种。未发现抗菌药物耐药性的最小证据，也未鉴定出具有异常或临床显著多重耐药模式的菌株。总体而言，这些发现将有助于优化选择合适的抗菌药物来治疗海獭和其他海洋物种的细菌性疾病。
