血清素和训练诱导的海兔 CREB2 的动态调节。
Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia.
机构信息
Department of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, The University of Texas Medical School at Houston, Texas 77030, USA.
出版信息
Learn Mem. 2011 Mar 25;18(4):245-9. doi: 10.1101/lm.2112111. Print 2011.
Abstract
Long-term memory and plasticity, including long-term synaptic facilitation (LTF) of the Aplysia sensorimotor synapse, depend on the activation of transcription factors that regulate genes necessary for synaptic plasticity. In the present study we found that treatment with 5-HT and behavioral training produce biphasic changes in the expression of CREB2, a transcriptional repressor. An immediate increase in CREB2 protein was followed by a subsequent decrease. The effects of these treatments persist for at least 24 h and are observed in isolated sensory neurons. This study suggests that the dynamics of CREB2 expression could contribute to the consolidation of memory.
摘要
长期记忆和可塑性，包括 Aplysia 感觉运动突触的长时程突触易化 (LTF)，取决于转录因子的激活，这些转录因子调节突触可塑性所必需的基因。在本研究中，我们发现 5-HT 处理和行为训练会导致转录抑制因子 CREB2 的表达产生双峰变化。CREB2 蛋白的立即增加后随之减少。这些处理的影响至少持续 24 小时，并在分离的感觉神经元中观察到。本研究表明，CREB2 表达的动态变化可能有助于记忆的巩固。
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