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Towards personalized medicine - the role of methotrexate.

作者信息

Naik Sita

机构信息

Former Professor & Head, Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow 226 014, India.

出版信息

Indian J Med Res. 2011 Mar;133(3):253-5.

PMID:21441677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3103148/
Abstract
摘要

相似文献

1
Towards personalized medicine - the role of methotrexate.迈向个性化医疗——甲氨蝶呤的作用
Indian J Med Res. 2011 Mar;133(3):253-5.
2
Defining the optimal dosage of methotrexate for childhood acute lymphoblastic leukemia. New insights from the lab and clinic.确定儿童急性淋巴细胞白血病甲氨蝶呤的最佳剂量。来自实验室和临床的新见解。
Adv Exp Med Biol. 1999;457:537-41. doi: 10.1007/978-1-4615-4811-9_58.
3
Repeated Episodes of Leukoencephalopathy after High-dose Methotrexate in a Child with Acute Lymphoblastic Leukemia.一名急性淋巴细胞白血病患儿在接受高剂量甲氨蝶呤治疗后反复出现白质脑病发作。
Indian Pediatr. 2017 Feb 15;54(2):159.
4
[Radiological case of the month. Leukoencephalopathy caused by methotrexate in a child treated for acute lymphoblastic leukemia].[本月放射病例。一名接受急性淋巴细胞白血病治疗的儿童因甲氨蝶呤导致的白质脑病]
Arch Pediatr. 1996 Jan;3(1):85-7. doi: 10.1016/s0929-693x(96)80016-9.
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Does pharmacokinetic variability influence the efficacy of high-dose methotrexate for the treatment of children with acute lymphoblastic leukemia: what can we learn from small studies?
Leuk Res. 1997 May;21(5):435-7. doi: 10.1016/s0145-2126(96)00128-2.
6
Reduced elimination of Methotrexate in an adult with trisomy 21 and acute lymphoblastic leukaemia.
Leuk Res. 2007 Oct;31(10):1452-3. doi: 10.1016/j.leukres.2006.11.005. Epub 2006 Dec 18.
7
Treatment of Czech children with acute lymphoblastic leukemia: a report of the Czech Working Group for Pediatric Hematology.捷克儿童急性淋巴细胞白血病的治疗：捷克儿科血液学工作组报告
Med Pediatr Oncol. 2002 Aug;39(2):125-7. doi: 10.1002/mpo.1371.
8
[Resistance mechanisms to Methotrexate].
Zhonghua Er Ke Za Zhi. 2003 May;41(5):388-90.
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'Stroke-like syndrome' caused by intrathecal methotrexate in patients treated during the UKALL 2003 trial.在英国ALL 2003试验期间接受治疗的患者中，鞘内注射甲氨蝶呤引起的“类中风综合征”
Leukemia. 2013 Apr;27(4):954-6. doi: 10.1038/leu.2012.328. Epub 2012 Nov 14.
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Genetic polymorphisms of folate metabolic enzymes and toxicities of high dose methotrexate in children with acute lymphoblastic leukemia.急性淋巴细胞白血病患儿叶酸代谢酶的基因多态性与高剂量甲氨蝶呤的毒性
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本文引用的文献

1
Profiling single nucleotide polymorphisms (SNPs) across intracellular folate metabolic pathway in healthy Indians.在健康的印度人群体中分析细胞内叶酸代谢途径中的单核苷酸多态性（SNPs）。
Indian J Med Res. 2011 Mar;133(3):274-9.
2
Synovial tissue heterogeneity in rheumatoid arthritis in relation to disease activity and biomarkers in peripheral blood.类风湿关节炎中滑膜组织异质性与疾病活动及外周血生物标志物的关系
Arthritis Rheum. 2010 Jun;62(6):1602-7. doi: 10.1002/art.27415.
3
Associations between the C677T and A1298C polymorphisms of MTHFR and the efficacy and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis.MTHFR 基因 C677T 和 A1298C 多态性与甲氨蝶呤治疗类风湿关节炎疗效和毒性的关系：荟萃分析。
Clin Drug Investig. 2010;30(2):101-8. doi: 10.2165/11531070-000000000-00000.
4
Can rheumatoid arthritis responsiveness to methotrexate and biologics be predicted?类风湿关节炎对甲氨蝶呤和生物制剂的反应性可以预测吗？
Rheumatology (Oxford). 2009 Sep;48(9):1021-8. doi: 10.1093/rheumatology/kep112. Epub 2009 May 29.
5
Interaction of genes from influx-metabolism-efflux pathway and their influence on methotrexate efficacy in rheumatoid arthritis patients among Indians.流入-代谢-流出途径相关基因的相互作用及其对印度类风湿关节炎患者甲氨蝶呤疗效的影响。
Pharmacogenet Genomics. 2008 Dec;18(12):1041-9. doi: 10.1097/fpc.0b013e328311a8fd.
6
Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid.叶酸拮抗剂4-氨基蝶酰谷氨酸诱导儿童急性白血病的暂时缓解。
N Engl J Med. 1948 Jun 3;238(23):787-93. doi: 10.1056/NEJM194806032382301.
7
A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis.一种预测甲氨蝶呤单药治疗新发类风湿关节炎疗效的临床药物遗传学模型。
Arthritis Rheum. 2007 Jun;56(6):1765-75. doi: 10.1002/art.22640.
8
Correlation between methotrexate efficacy & toxicity with C677T polymorphism of the methylenetetrahydrofolate gene in rheumatoid arthritis patients on folate supplementation.补充叶酸的类风湿关节炎患者中，甲氨蝶呤疗效及毒性与亚甲基四氢叶酸还原酶基因C677T多态性的相关性
Indian J Med Res. 2006 Nov;124(5):521-6.
9
ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arthritis patients.ABCB1基因C3435T多态性影响类风湿关节炎患者对甲氨蝶呤的敏感性。
Clin Exp Rheumatol. 2006 Sep-Oct;24(5):546-54.
10
Cost-effectiveness analysis of MTHFR polymorphism screening by polymerase chain reaction in Korean patients with rheumatoid arthritis receiving methotrexate.韩国类风湿关节炎患者接受甲氨蝶呤治疗时通过聚合酶链反应进行亚甲基四氢叶酸还原酶基因多态性筛查的成本效益分析
J Rheumatol. 2006 Jul;33(7):1266-74. Epub 2006 Jun 1.