• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Does pharmacokinetic variability influence the efficacy of high-dose methotrexate for the treatment of children with acute lymphoblastic leukemia: what can we learn from small studies?

作者信息

Evans W E, Relling M V, Boyett J M, Pui C H

机构信息

Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN 38101, USA.

出版信息

Leuk Res. 1997 May;21(5):435-7. doi: 10.1016/s0145-2126(96)00128-2.

DOI:10.1016/s0145-2126(96)00128-2
PMID:9225072
Abstract
摘要

相似文献

1
Does pharmacokinetic variability influence the efficacy of high-dose methotrexate for the treatment of children with acute lymphoblastic leukemia: what can we learn from small studies?
Leuk Res. 1997 May;21(5):435-7. doi: 10.1016/s0145-2126(96)00128-2.
2
Defining the optimal dosage of methotrexate for childhood acute lymphoblastic leukemia. New insights from the lab and clinic.确定儿童急性淋巴细胞白血病甲氨蝶呤的最佳剂量。来自实验室和临床的新见解。
Adv Exp Med Biol. 1999;457:537-41. doi: 10.1007/978-1-4615-4811-9_58.
3
On the prognostic value of systemic methotrexate clearance in childhood acute lymphocytic leukemia.关于全身甲氨蝶呤清除率在儿童急性淋巴细胞白血病中的预后价值。
Leuk Res. 1997 May;21(5):429-34. doi: 10.1016/s0145-2126(96)00127-0.
4
[Assessment of elimination and tolerance of high dose of methotrexate (3 g/m2) in children with standard-risk acute lymphoblastic leukemia].[标准风险急性淋巴细胞白血病患儿高剂量甲氨蝶呤(3 g/m²)的清除率及耐受性评估]
Przegl Lek. 2006;63(1):15-20.
5
Methotrexate pharmacokinetics in childhood acute lymphoblastic leukaemia: a prognostic value?甲氨蝶呤在儿童急性淋巴细胞白血病中的药代动力学:预后价值?
J Clin Pharm Ther. 2011 Apr;36(2):237-45. doi: 10.1111/j.1365-2710.2010.01179.x. Epub 2010 Oct 19.
6
Population PK/PD model of homocysteine concentrations after high-dose methotrexate treatment in patients with acute lymphoblastic leukemia.高剂量甲氨蝶呤治疗急性淋巴细胞白血病患者后同型半胱氨酸浓度的群体 PK/PD 模型。
PLoS One. 2012;7(9):e46015. doi: 10.1371/journal.pone.0046015. Epub 2012 Sep 25.
7
The interaction of 6-mercaptopurine (6-MP) and methotrexate (MTX).6-巯基嘌呤(6-MP)与甲氨蝶呤(MTX)的相互作用。
Gen Pharmacol. 1999 Oct;33(4):341-6. doi: 10.1016/s0306-3623(99)00022-1.
8
Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia.
Leuk Lymphoma. 1996 May;21(5-6):359-68. doi: 10.3109/10428199609093433.
9
Population pharmacokinetics of methotrexate in Mexican pediatric patients with acute lymphoblastic leukemia.墨西哥儿童急性淋巴细胞白血病患者甲氨蝶呤的群体药代动力学。
Cancer Chemother Pharmacol. 2020 Jan;85(1):21-31. doi: 10.1007/s00280-019-03977-1. Epub 2019 Oct 31.
10
Relationship between oral mucositis and high-dose methotrexate therapy in pediatric acute lymphoblastic leukemia.小儿急性淋巴细胞白血病中口腔黏膜炎与大剂量甲氨蝶呤治疗的关系
Int J Clin Pharmacol Ther. 2008 Nov;46(11):584-90. doi: 10.5414/cpp46584.

引用本文的文献

1
The Role of Candidate Polymorphisms in Drug Transporter Genes on High-Dose Methotrexate in the Consolidation Phase of the AIEOP-BFM ALL 2009 Protocol.候选多态性在药物转运体基因中对AIEOP-BFM ALL 2009方案巩固期大剂量甲氨蝶呤的作用
Clin Transl Sci. 2025 Feb;18(2):e70136. doi: 10.1111/cts.70136.
2
Population Pharmacokinetics of High-Dose Methotrexate in Chinese Pediatric Patients With Acute Lymphoblastic Leukemia.大剂量甲氨蝶呤在中国急性淋巴细胞白血病儿童患者中的群体药代动力学
Front Pharmacol. 2021 Jul 13;12:701452. doi: 10.3389/fphar.2021.701452. eCollection 2021.
3
Evaluation of body-surface-area adjusted dosing of high-dose methotrexate by population pharmacokinetics in a large cohort of cancer patients.
采用群体药代动力学方法评价大样本癌症患者中甲氨蝶呤高剂量给药时体表面积校正剂量。
BMC Cancer. 2021 Jun 20;21(1):719. doi: 10.1186/s12885-021-08443-x.
4
Population pharmacokinetics of high-dose methotrexate in children with acute lymphoblastic leukaemia.大剂量甲氨蝶呤在急性淋巴细胞白血病儿童中的群体药代动力学。
Clin Pharmacokinet. 2006;45(12):1227-38. doi: 10.2165/00003088-200645120-00007.
5
From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates.从甲氨蝶呤到培美曲塞及其他。抗叶酸药物的药效学和临床特性综述。
Invest New Drugs. 2006 Jan;24(1):37-77. doi: 10.1007/s10637-005-4541-1.