发现鸡贫血病毒的一个远亲的基因组，揭示了一个新的回转病毒属成员。
Discovery of a genome of a distant relative of chicken anemia virus reveals a new member of the genus Gyrovirus.
机构信息
Virology Laboratory, Microbiology Department, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS), Av. Sarmento Leite 500, Porto Alegre, Rio Grande do Sul (RS), CEP 90050-170, Brazil.
出版信息
Arch Virol. 2011 Jun;156(6):1097-100. doi: 10.1007/s00705-011-0971-6. Epub 2011 Mar 26.
A 2.4-kb phi29 polymerase amplification product from serum of a diseased chicken was cloned and sequenced. The 2383-nucleotide sequence showed about 40% identity to a representative genome of chicken anemia virus (CAV), the only member of the genus Gyrovirus, family Circoviridae. The new genome had an organization similar to that of CAV: a putative 5' untranscribed region of about 400 nt followed by three partially overlapping open reading frames encoding VP1, VP2 and VP3 homologs. The amino acid identities between these homologs and those of CAV were 38.8%, 40.3%, and 32.2%, respectively. Based on these limited similarities, it is proposed that the newly identified virus is a member of a new species in the genus Gyrovirus. For this new species, the name Avian gyrovirus 2 (AGV2) is proposed.
从患病鸡的血清中克隆并测序了一个 2.4kb 的 phi29 聚合酶扩增产物。该 2383 个核苷酸的序列与鸡贫血病毒（CAV）的一个代表基因组有大约 40%的同源性，CAV 是环状病毒科 Gyrovirus 属的唯一成员。新基因组的组织与 CAV 相似：大约 400 个核苷酸的假定 5'非转录区，其后是三个部分重叠的开放阅读框，编码 VP1、VP2 和 VP3 同源物。这些同源物与 CAV 的氨基酸同一性分别为 38.8%、40.3%和 32.2%。基于这些有限的相似性，建议新鉴定的病毒是 Gyrovirus 属的一个新种成员。对于这个新种，建议命名为禽环曲病毒 2（AGV2）。
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