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鸡贫血病毒假定基因间重组体的鉴定

Identification of chicken anemia virus putative intergenotype recombinants.

作者信息

He Cheng-Qiang, Ding Nai-Zheng, Fan Wei, Wu Yan-Hong, Li Jing-Peng, Li Yun-long

机构信息

College of Life Science, Shandong Normal University, Jinan 250014, China.

出版信息

Virology. 2007 Sep 15;366(1):1-7. doi: 10.1016/j.virol.2007.06.007. Epub 2007 Jul 5.

Abstract

Chicken anemia virus (CAV), the only member of the genus Gyrovirus in the family Circoviridae is the pathogen of chicken infectious anemia. It is unknown whether homologous recombination happens between CAV strains. In order to gain insight into this matter, we have performed a phylogenetic analysis of full-length CAV strains isolated to detect possible recombination events. Two putative recombinants, SD24, SD22 and the putative parental-like strains were identified with the use of SimPlot program. The two mosaic CAV consist of a novel genotype in the phylogenetic tree. It suggests that homologous recombinant plays roles in generating genetic diversity in natural populations of CAV.

摘要

鸡贫血病毒(CAV)是圆环病毒科环曲病毒属的唯一成员,是鸡传染性贫血的病原体。CAV毒株之间是否发生同源重组尚不清楚。为了深入了解这一问题,我们对分离的全长CAV毒株进行了系统发育分析,以检测可能的重组事件。使用SimPlot程序鉴定出两个推定的重组体SD24、SD22以及推定的亲本样毒株。这两个嵌合型CAV在系统发育树中构成一个新的基因型。这表明同源重组在CAV自然群体的遗传多样性产生中发挥作用。

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