Lesage A D, Trapani V, Tansella M
Psychiatric Research Center, Louis-H. Lafontaine Hospital, Montréal, Québec, Canada.
Eur Arch Psychiatry Neurol Sci. 1990;239(6):361-5. doi: 10.1007/BF01734542.
The risk of mortality over a 5- to 8-year period for a total 1-year prevalence cohort of schizophrenic patients extracted by means of the South-Verona Psychiatric Case Register (Italy) was assessed using three methods: (1) case control with both non-psychotic patients and the general population matched for sex and age; (2) indirect standardization using mortality tables; (3) a recently described method using survival tables. All methods yielded an excess mortality associated with schizophrenia, close to the two-fold increase described in other studies, while the survival tables method produced a higher standardized mortality ratio (SMR). The increased SMR did not appear solely attributable to suicide. Most deaths were attributable to natural causes. This is a departure from other recently reported mortality studies. The possible reasons are discussed.
利用南维罗纳精神病病例登记册（意大利）选取了一组精神分裂症患者，该组患者的1年患病率为总体患病率，采用三种方法评估了这些患者在5至8年期间的死亡风险：（1）与非精神病患者和按性别及年龄匹配的普通人群进行病例对照研究；（2）使用死亡率表进行间接标准化；（3）一种最近描述的使用生存表的方法。所有方法均得出精神分裂症相关的超额死亡率，接近其他研究中描述的两倍增长，而生存表方法得出的标准化死亡率（SMR）更高。SMR升高似乎并非仅归因于自杀。大多数死亡归因于自然原因。这与其他近期报道的死亡率研究不同。文中讨论了可能的原因。
