Wroclaw Medical University, Wroclaw, Poland.
Acta Diabetol. 2013 Apr;50(2):217-25. doi: 10.1007/s00592-011-0280-2. Epub 2011 Mar 27.
The objective of this study was to prospectively evaluate the impact of diabetes on HRQOL at baseline and 6-months following ACS treated by PCI and to determine which predictors: demographic, clinical, and other variables influence QOL results in physical component summary (PCS) and mental component summary (MCS) of SF-36 health survey. The 120 consecutive patients (mean age 62.5, SD ± 9.8) with acute coronary syndrome ACS including non-ST-elevation myocardial infarction NSTEMI, n = 60 and ST-elevation myocardial infarction STEMI, n = 60 were entered into the study. Each patient was prospectively interviewed at baseline (at discharge) and 6-months following ACS. We relied on previously validated questionnaire to assess the patient's overall health perception, namely the SF-36 health survey. Generally, the whole group demonstrated the better PCS score at 6-month follow-up: 54.7 versus 55.5; P < 0.0001. With regard to PCS, an increase in life quality results was observed in both groups. However, it should be emphasize that the diabetic group demonstrated considerably lower life quality baseline. Also, the whole group demonstrated better MCS score at 6-month follow-up: 55.9 versus 56.5; P < 0.0001. The influence of diabetes, multivessel disease, hypertension, and the high triglyceride level have negative impact on life quality evaluation, whereas male patients and patients with ACS-STEMI had better quality of life results. The influence of diabetes, multivessel disease, hypertension, and the high triglyceride level have negative impact on life quality evaluation, whereas male patients and patients with ACS-STEMI had better quality of life results. The influence of diabetes, the history of myocardial infarction, and the high triglyceride level have negative impact on life quality evaluation. Patients with ACS-STEMI had better quality of life results. The influence of diabetes, the history of myocardial infarction, and the high triglyceride level have negative impact on quality of life evaluation. Male patients had better quality of life results. (1) Diabetic patients obtain worse life quality results than non-diabetic patients, both at baseline and 6-months following PCI. (2) Positive predictors of patient's life quality are the male sex and clinical manifestation of the disease (STEMI). (3) As regards PCS, negative predictors of patient's life quality are diabetes, multivessel disease, high triglyceride level, and arterial hypertension. (4) As regards MCS, negative predictors are diabetes, the history of myocardial infarction, and high triglyceride level.
本研究旨在前瞻性评估糖尿病对经 PCI 治疗的急性冠脉综合征（ACS）患者基线和 6 个月时 HRQOL 的影响，并确定哪些预测因素：人口统计学、临床和其他变量会影响 SF-36 健康调查的身体成分摘要（PCS）和心理成分摘要（MCS）的 QOL 结果。120 例连续患者（平均年龄 62.5，SD±9.8）入选本研究，包括非 ST 段抬高型心肌梗死 NSTEMI，n=60 和 ST 段抬高型心肌梗死 STEMI，n=60。每位患者均在基线（出院时）和 ACS 后 6 个月进行前瞻性访谈。我们依靠先前经过验证的问卷评估患者的整体健康感知，即 SF-36 健康调查。一般来说，整个组在 6 个月随访时表现出更好的 PCS 评分：54.7 对 55.5；P<0.0001。关于 PCS，两组的生活质量均有所提高。然而，应该强调的是，糖尿病组的基线生活质量较低。此外，整个组在 6 个月随访时表现出更好的 MCS 评分：55.9 对 56.5；P<0.0001。糖尿病、多血管疾病、高血压和高甘油三酯水平的影响对生活质量评估产生负面影响，而男性患者和 ACS-STEMI 患者的生活质量结果更好。糖尿病、多血管疾病、高血压和高甘油三酯水平的影响对生活质量评估产生负面影响，而男性患者和 ACS-STEMI 患者的生活质量结果更好。糖尿病、心肌梗死史和高甘油三酯水平的影响对生活质量评估产生负面影响。ACS-STEMI 患者的生活质量结果更好。糖尿病、心肌梗死史和高甘油三酯水平的影响对生活质量评估产生负面影响。男性患者的生活质量结果更好。（1）与非糖尿病患者相比，糖尿病患者在 PCI 后基线和 6 个月时的生活质量均较差。（2）患者生活质量的阳性预测因素是男性和疾病的临床表现（STEMI）。（3）就 PCS 而言，患者生活质量的负面预测因素是糖尿病、多血管疾病、高甘油三酯水平和动脉高血压。（4）就 MCS 而言，负面预测因素是糖尿病、心肌梗死史和高甘油三酯水平。
