Department of Psychiatry, Zentrum für Integrative Psychiatrie, Kiel, Germany.
Mov Disord. 2011 Aug 1;26(9):1741-4. doi: 10.1002/mds.23699. Epub 2011 Mar 25.
Quality of life in Parkinson patients with subthreshold depression could be improved if the prevalence and symptom profile were better understood.
Our study used standard DSM-IV and Judd criteria as well as motor, depression, and quality-of-life scales to investigate a sample of 110 nondemented Parkinson patients. This led to formation of nondepressed (48.2%), subthreshold depressed (25.5%), and depressed (26.4%) groups.
Quality of life was seen to be significantly lower in subthreshold depressed patients than in the nondepressed, and there were differences in the frequency of depressive symptoms that partially overlapped with nonmotor symptoms of vegetative origin in Parkinson's disease (appetite, sleep disorders). Key measures of depression (diminished interest/pleasure) were more frequent in the depressed group compared with the subthreshold depressed, although the motor functions of these 2 groups did not differ significantly.
The Beck Depression Inventory score ranging from 9 to 15 points differentiates subthreshold depressed from nondepressed and depressed patients best.
如果更好地了解亚临床抑郁的帕金森病患者的患病率和症状特征，他们的生活质量可能会得到改善。
我们的研究使用了标准的 DSM-IV 和 Judd 标准以及运动、抑郁和生活质量量表，对 110 名非痴呆帕金森病患者进行了调查。这导致了非抑郁（48.2%）、亚临床抑郁（25.5%）和抑郁（26.4%）组的形成。
亚临床抑郁患者的生活质量明显低于非抑郁患者，并且在抑郁症状的频率上存在差异，这些症状部分与帕金森病的非运动性自主神经症状重叠（食欲、睡眠障碍）。与亚临床抑郁组相比，抑郁组的关键抑郁指标（兴趣/乐趣减退）更为常见，尽管这两组的运动功能没有显著差异。
贝克抑郁量表评分在 9 到 15 分之间，能最好地区分亚临床抑郁与非抑郁和抑郁患者。
