大鼠在戊巴比妥与咪达唑仑/芬太尼/氟胺酮麻醉期间的心输出量分布

Distribution of cardiac output during pentobarbital versus midazolam/fentanyl/fluanisone anaesthesia in the rat.

作者信息

Skolleborg K C, Grönbech J E, Grong K, Abyholm F E, Lekven J

机构信息

Surgical Research Laboratory, University of Bergen, Norway.

出版信息

Lab Anim. 1990 Jul;24(3):221-7. doi: 10.1258/002367790780866100.

DOI:10.1258/002367790780866100

PMID:2144326

Abstract

Differences in effects on central haemodynamics, organ blood flow, and serum corticosterone were studied in 11 rats anaesthetized with midazolam/fentanyl/fluanisone (MFF) and 11 other rats anaesthetized with sodium pentobarbital. Compared with pentobarbital, MFF reduced aortic blood pressure by 25%, increased heart rate by 20%, and increased cardiac output by 80%. Unlike most tissues, MFF produced a fivefold increase in blood flow to skeletal muscle, and decreased adrenal blood flow compared to pentobarbital anaesthesia. Initial serum corticosterone levels were lower in rats given MFF anaesthesia, indicating better stress protection. This study also indicates that MFF anaesthesia is preferable to pentobarbital because tissue perfusion generally was better preserved.

摘要

在11只使用咪达唑仑/芬太尼/氟胺酮（MFF）麻醉的大鼠和11只使用戊巴比妥钠麻醉的大鼠中，研究了对中心血流动力学、器官血流量和血清皮质酮的影响差异。与戊巴比妥相比，MFF使主动脉血压降低25%，心率增加20%，心输出量增加80%。与大多数组织不同，与戊巴比妥麻醉相比，MFF使骨骼肌血流量增加了五倍，并减少了肾上腺血流量。接受MFF麻醉的大鼠初始血清皮质酮水平较低，表明应激保护更好。这项研究还表明，MFF麻醉比戊巴比妥更可取，因为组织灌注总体上得到了更好的维持。