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用小米粥加青蒿治疗非洲疟疾儿童?

Millet-porridge with Artemisia annua as first aid for African children with malaria?

机构信息

Laboratory for Mother and Child Health, Department of Public Health, Mario Negri Pharmacological Research Institute, Via G. La Masa 19, Milan, Italy.

出版信息

J Altern Complement Med. 2011 Apr;17(4):371-3. doi: 10.1089/acm.2010.0252. Epub 2011 Mar 28.

DOI:10.1089/acm.2010.0252
PMID:21443445
Abstract

OBJECTIVES

In a few malaria-endemic countries with high disease prevalence, especially in children, and local cultivation of Artemisia annua, the availability of recommended malaria medicines is scant. New sources of treatment could be used, drawing from traditional medicine.

METHODS

A popular African millet-porridge was prepared by adding dried, sieved leaves of Artemisia annua. Artemisinin concentrations were detected by high-performance liquid chromatography-mass spectrometry.

RESULTS

The artemisinin content of the porridge is stable and the concentration is maintained. The taste of the porridge is palatable.

CONCLUSIONS

Further research is needed before proposing the millet-porridge artemisinin formulation, but such an affordable therapy could be an option in the near future (also) for children living in poor areas where access to effective antimalarial drugs is precluded.

摘要

目的

在少数疟疾流行且发病率高的国家,特别是在儿童中,以及在青蒿素当地种植的地方,推荐的抗疟药物供应稀缺。可以利用传统医学寻找新的治疗方法。

方法

将青蒿的干、筛过的叶子加入到一种受欢迎的非洲小米粥中。通过高效液相色谱-质谱法检测青蒿素浓度。

结果

小米粥中的青蒿素含量稳定且浓度保持不变。小米粥的味道可口。

结论

在提出小米粥青蒿素配方之前,还需要进一步研究,但对于生活在难以获得有效抗疟药物的贫困地区的儿童来说,这种负担得起的治疗方法可能是一个选择。

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引用本文的文献

1
Simulated digestion of dried leaves of Artemisia annua consumed as a treatment (pACT) for malaria.模拟消化作为疟疾治疗方法食用的青蒿干叶(pACT)。
J Ethnopharmacol. 2014 Feb 3;151(2):858-63. doi: 10.1016/j.jep.2013.11.043. Epub 2013 Dec 6.