Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, 75-59 263rd Street, Glen Oaks, NY 11004, USA.
Bipolar Disord. 2011 Mar;13(2):164-72. doi: 10.1111/j.1399-5618.2011.00906.x.
Bipolar disorder (BD) has been associated with impairment in affective processing during depressive and manic states; however, there are limited data as to whether this population exhibits such difficulty during stable periods. We examined the pattern of affective processing in stable BD patients and compared their profile to that of healthy controls (HC) and patients diagnosed with schizophrenia (SZ).
A total of 336 subjects were administered an Affective Go/No-go test to evaluate target detection of negatively valenced, positively valenced, and neutral stimuli. Accuracy and response bias served as dependent variables in a series of multivariate analyses of covariance to test for group differences.
The BD group relative to the HC group exhibited response biases toward negatively valenced information (p<0.01). Deficits were also evident in discrimination of and accurate responses to positively valenced information in the BD group versus the HC group (p<0.05). In contrast to the controls, the SZ group performed poorly on all task components and was less accurate across all conditions regardless of affective valence (p<0.01). Patients with SZ evidenced reverse biases for positive information, as they were less likely to respond to positive words (p<0.05) despite comparable response bias on neutral and negative conditions.
Affective processing impairment evident in BD is a feature of the disorder that is present even during stable periods. Prior studies comparing BD with SZ have highlighted clear quantitative but inconsistent qualitative differences in cognitive functioning. Our data suggest that a response bias toward negative stimuli may be a critical and relatively specific feature of BD.
双相情感障碍（BD）与抑郁和躁狂状态下的情感处理受损有关；然而，关于该人群在稳定期是否存在这种困难的数据有限。我们研究了稳定期 BD 患者的情感处理模式，并将其与健康对照组（HC）和精神分裂症（SZ）患者进行了比较。
共有 336 名受试者接受了情感 Go/No-go 测试，以评估对负性、正性和中性刺激的目标检测。准确性和反应偏差作为一系列协方差多元分析的因变量，用于测试组间差异。
BD 组相对于 HC 组对负性信息表现出反应偏差（p<0.01）。BD 组与 HC 组相比，对正性信息的辨别和准确反应也存在缺陷（p<0.05）。与对照组不同的是，SZ 组在所有任务成分上表现不佳，无论情感效价如何，准确性都较低（p<0.01）。SZ 患者对正性信息表现出反向偏差，因为他们不太可能对正性词汇做出反应（p<0.05），尽管在中性和负性条件下的反应偏差相当。
BD 中明显的情感处理受损是该疾病的一个特征，即使在稳定期也存在。先前比较 BD 与 SZ 的研究强调了认知功能的明显定量但不一致的定性差异。我们的数据表明，对负性刺激的反应偏差可能是 BD 的一个关键且相对特异的特征。
