Rossell Susan L, Van Rheenen Tamsyn E, Joshua Nicole R, O'Regan Alison, Gogos Andrea
Brain and Psychological Sciences Research Centre, Faculty of Health, Arts and Design, Swinburne University, John St, Hawthorn, Victoria 3122, Australia; Cognitive Neuropsychiatry Laboratory, Monash Alfred Psychiatry Research Centre (MAPrc), Level 4, 607 St Kilda Rd, Melbourne, Victoria 3004, Australia; Mental Health Research Institute of Victoria, Victoria 3053, Australia(1); The University of Melbourne, Parkville, Victoria 3010, Australia; Psychiatry, St Vincent's Hospital, Melbourne 3065, Australia.
Brain and Psychological Sciences Research Centre, Faculty of Health, Arts and Design, Swinburne University, John St, Hawthorn, Victoria 3122, Australia; Cognitive Neuropsychiatry Laboratory, Monash Alfred Psychiatry Research Centre (MAPrc), Level 4, 607 St Kilda Rd, Melbourne, Victoria 3004, Australia.
Schizophr Res. 2014 Aug;157(1-3):55-9. doi: 10.1016/j.schres.2014.05.026. Epub 2014 Jun 9.
Facial affect processing (FAP) deficits in schizophrenia (SZ) and bipolar disorder (BD) have been widely reported; although effect sizes vary across studies, and there are limited direct comparisons of the two groups. Further, there is debate as to the influence of both psychotic and mood symptoms on FAP. This study aimed to address these limitations by recruiting groups of psychosis patients with either a diagnosis of SZ or BD and comparing them to healthy controls (HC) on a well validated battery of four FAP subtests: affect discrimination, name affect, select affect and match affect. Overall, both groups performed more poorly than controls in terms of accuracy. In SZ, this was largely driven by impairments on three of the four subtests. The BD patients showed impaired performance specifically on the match affect subtest, a task that had a high cognitive load. FAP performance in the psychosis patients was correlated with severity of positive symptoms and mania. This study confirmed that FAP deficits are a consistent finding in SZ that occur independent of task specific methodology; whilst FAP deficits in BD are more subtle. Further work in this group is needed to replicate these results.
精神分裂症（SZ）和双相情感障碍（BD）患者的面部表情加工（FAP）缺陷已被广泛报道；尽管各研究的效应大小有所不同，且两组之间的直接比较有限。此外，关于精神病性症状和情绪症状对FAP的影响也存在争议。本研究旨在通过招募诊断为SZ或BD的精神病患者组，并将他们与健康对照（HC）在一组经过充分验证的四个FAP子测试上进行比较，以解决这些局限性：情感辨别、命名情感、选择情感和匹配情感。总体而言，两组在准确性方面的表现均比对照组差。在SZ中，这主要是由四个子测试中的三个测试的损伤所驱动。BD患者在匹配情感子测试中表现受损，该任务具有较高的认知负荷。精神病患者的FAP表现与阳性症状和躁狂的严重程度相关。本研究证实，FAP缺陷是SZ中一个一致的发现，其发生独立于特定任务的方法；而BD中的FAP缺陷则更为微妙。需要在该组中进一步开展工作以重复这些结果。
