Inserm CIC3, Grenoble Clinical Research Center, Grenoble University Hospital, Grenoble, France.
Microcirculation. 2011 Aug;18(6):448-51. doi: 10.1111/j.1549-8719.2011.00105.x.
Sildenafil is a type 5 phosphodiesterase inhibitor that has a theoretical ability to increase hyperemia following a short bout of ischemia. We tested if oral sildenafil increases skin PORH in healthy volunteers.
We assessed forearm skin PORH (occlusion of blood flow for five minutes) in ten healthy volunteers 120minutes following the oral administration of 50 or 100mg of sildenafil. Cutaneous blood flow on the forearm was monitored using LDF.
The PORH peak, expressed as a percentage of baseline, was clearly increased with 100mg sildenafil: 746% (95% CI 447-1044) versus 484% (95% CI 354-613) with 50mg sildenafil, and 468% (95% CI 347-588) without sildenafil (p=0.03 for 100mg versus 50mg and control). Oral sildenafil at 50mg increased the AUC of PORH on the forearm compared with control: 4568PU.sec (95% CI: 2252-6883) with 50mg sildenafil versus 1030 PU.sec (95% CI 737-1322) without sildenafil (p=0.006). Likewise, 100mg sildenafil increased the AUC (5271PU.sec (95% CI -81-10,623), albeit bordering on significance (p=0.07). Neither dose increased maximal LTH.
Acute sildenafil administration at 50 and 100mg enhances skin hyperemia following a short bout of ischemia.
西地那非是一种 5 型磷酸二酯酶抑制剂，理论上具有增加短暂缺血后充血的能力。我们测试了口服西地那非是否会增加健康志愿者的皮肤 PORH。
我们在 10 名健康志愿者中评估了口服 50 或 100mg 西地那非后 120 分钟时的前臂皮肤 PORH（血流阻断 5 分钟）。使用 LDF 监测前臂的皮肤血流。
PORH 峰值以基线的百分比表示，100mg 西地那非明显增加：746%（95%CI 447-1044）与 50mg 西地那非的 484%（95%CI 354-613）相比，与无西地那非的 468%（95%CI 347-588）相比（p=0.03 用于 100mg 与 50mg 和对照）。与对照相比，50mg 西地那非口服增加了前臂 PORH 的 AUC：4568PU.sec（95%CI：2252-6883）与 50mg 西地那非无 1030 PU.sec（95%CI 737-1322）（p=0.006）。同样，100mg 西地那非增加了 AUC（5271PU.sec（95%CI -81-10,623），尽管接近显著性（p=0.07）。两种剂量均未增加最大 LTH。
急性给予 50 和 100mg 西地那非可增强短暂缺血后的皮肤充血。
